Immunoglobulins and complement in the skin of rhesus monkeys immunized with x-irradiated cercariae of Schistosoma japonicum

Zeitschrift Für Parasitenkunde
S Y HsüH O Hanson

Abstract

Skin sections of rhesus monkeys immunized with X-irradiated Schistosoma japonicum cercariae were stained by an unlabeled antibody enzyme method for the detection of IgG, IgM, IgA, IgE, and C3. While all of them could be found in the skin lesions, their distribution patterns varied with time and reactions. In whealing reaginic reactions, IgE appeared prominent, having an affinity to the mast cells. In Arthus-like reactions, IgG was predominant. IgG complexes were found on the schistosomula, on the walls of blood vessels, and in granulocytes near the schistosomula. In the late stage of Arthus-like reactions and in delayed hypersensitive reactions, IgA was predominant in granulocytes, mononuclear cells, and macrophages. Characteristics of each immunoglobulin pattern seemed to reflect its function in the effector mechanism. It may be speculated that these immunoglobulins and C3, together with effector cells, synergistically and sequentially destroy schistosomula in the skin.

References

Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·S M PhillipsB L Doughty
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Jan 1, 1976·International Archives of Allergy and Applied Immunology·A E ButterworthA B Wilson
Jan 1, 1974·Advances in Immunology·H L Spiegelberg
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Oct 22, 1971·Nature·G Taylor

Related Concepts

Metazoa
Immune complex
Arthus Reaction
Complement C3 precursor
Granulocyte
Delayed Hypersensitivity
IgA2
Immunoglobulin E
IgG2B
IgM2

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