Immunoglobulins and cytokines level in follicular fluid in relation to etiology of infertility and their relevance to IVF outcome

American Journal of Reproductive Immunology : AJRI
Mohamad Eid HammadehW Schmidt

Abstract

The aims of the present study were to (i) determine the presence and concentration of albumin fractions (alpha1, alpha2, beta, gamma), immunoglobulins (IgA, IgG, IgM) and cytokines [interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF)] in periovulatory ovarian follicular fluid (FF) of in vitro fertilization (IVF) patients, (ii) examine the relationship between these parameters and the etiology of infertility as well as the IVF outcome and (iii) find out if these parameters in FF could be used as a predictive factor of IVF outcome. The levels of albumin fractions, immunoglobulin and cytokines were measured from women who underwent IVF therapy for various indications and the results were compared between the patient groups and IVF outcome. Follicular fluid was obtained from 160 IVF patients. A total of 79 patients underwent controlled ovarian hyperstimulations (COH) either with follicle-stimulating hormone (FSH) or HMG. Whereas, the HMG was used for the second set of patients (n=81) - after down regulation with gondotropin-releasing hormone agonists (Gn-RHa) - the protein fractions were determined using electrophoresis separation. Immunoglobulins were measured using a commercial kits and the concent...Continue Reading

References

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Citations

Nov 4, 2010·Journal of Assisted Reproduction and Genetics·Tugba AltunLubna Pal
Jun 14, 2005·American Journal of Reproductive Immunology : AJRI·Sanja VujisićBozica Sokolić
Jan 25, 2005·American Journal of Reproductive Immunology : AJRI·Sanja VujisićAdriana Vince
Sep 17, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eusebio S PiresJohn C Herr
Oct 28, 2006·Biochimica Et Biophysica Acta·Stefania AngelucciCarmine Di Ilio
Jan 1, 2014·International Journal of Reproductive Medicine·N Ellissa BaskindVinay Sharma
Mar 20, 2020·Journal of Assisted Reproduction and Genetics·Jie YangYushi Meng

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