Immunoglobulins reactive with myelin basic protein promote CNS remyelination

Neurology
M RodriguezV A Lennon

Abstract

We tested the hypothesis that immunoglobulins directed against a CNS autoantigen, myelin basic protein, may promote remyelination in the course of a chronic, immune-mediated demyelinating disease. SJL/J mice infected chronically with Daniel's strain of Theiler's virus served as an experimental model of MS. The spinal cords of these mice exhibit extensive primary demyelination and inflammation with minimal spontaneous remyelination. Treatment with whole antiserum or affinity-purified mouse immunoglobulins directed against rat or rabbit myelin basic protein increased new myelin synthesis as measured by quantitative morphometry. Electron microscopy revealed numerous oligodendrocytes in remyelinated CNS lesions and a relative lack of inflammatory cells. Viral antigen persisted in the spinal cord despite enhanced CNS-type remyelination. These findings indicate that immunoglobulins reactive with myelin autoantigens have the potential to promote myelin repair.

Citations

Aug 10, 2000·Italian Journal of Neurological Sciences·B Currò DossiA Ravasio
Sep 26, 2006·Journal of Neurology·Ales Dudesek, Uwe K Zettl
Mar 5, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lisa SartiSabrina Matà
Apr 12, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Santosh B MurthyCorey E Goldsmith
Mar 14, 2007·Journal of Clinical Immunology·Vir-Singh NegiSrini V Kaveri
Nov 30, 2000·Current Treatment Options in Neurology·B Bielekova, R Martin
Feb 1, 2003·Journal of the Neurological Sciences·Per Soelberg Sorensen
Jan 18, 2003·Progress in Neurobiology·Martin Stangel, Hans-Peter Hartung
Aug 28, 2003·Lancet Neurology·Neil Scolding
Jul 27, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·U E Nydegger, T Sturzenegger
May 10, 2000·Clinical Neuropharmacology·J FinstererM Stiskal
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N Scolding
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Benjamin M Greenberg
Jul 5, 2012·PloS One·Branislav NastasijevicL James Maher
Jul 16, 2014·Experimental Neurology·T Bucky Jones
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Trevor Owens
May 27, 2011·Journal of Neuroimmunology·Farinaz SafaviForoozan Mokhtarian
Dec 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Fuat H SanerChristoph E Broelsch
Aug 29, 2006·Journal of Neuroimmunology·Jack Antel, Amit Bar-Or
Aug 3, 2010·Biochimica Et Biophysica Acta·Anne H Cross, Emmanuelle Waubant
May 21, 2015·Nucleic Acid Therapeutics·Weibin Li, Xiaopeng Lan
May 7, 2016·Experimental Neurology·Evan Z GoldsteinDana M McTigue
Dec 14, 2007·Neuro-degenerative Diseases·Per Soelberg Sorensen
Jun 11, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S H PelidouH Link
Jan 5, 2000·Multiple Sclerosis : Clinical and Laboratory Research·S MatàH Link
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·K Asakura, M Rodriguez
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
Mar 11, 1998·Multiple Sclerosis : Clinical and Laboratory Research·G S FrancisJ P Antel
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daren R Ure, Moses Rodriguez
Sep 24, 2020·Case Reports in Nephrology·D O BeraldoR A Teixeira
Dec 6, 2003·Brain Pathology·Bogoljub CiricLarry R Pease
Jan 1, 1999·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dorian McGavernMoses Rodriquez
Apr 20, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·D M WingerchukJ H Noseworthy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.