Immunohematopoietic stem cell transplantation: introduction and 35 years of development in South Africa--the historical and scientific perspective

Bone Marrow Transplantation
P Jacobs, L Wood

Abstract

Bone marrow was the traditional graft source when we introduced these procedures to South Africa. Technical details were established using rabbits as the experimental model with translation into a formally structured clinical programme at the University of Cape Town, based in the Groote Schuur Hospital, in 1972. Lack of any infrastructure was overcome by the acquisition of the first continuous-flow cell separator in sub-Sahara to provide for granulocyte transfusions. This was shortly followed by creating a dedicated platelet donor panel and establishing a specialized laboratory for clonogenic assays, flow cytometry, and programmed freezing and by including cryopreservation. Development was constant and seamless but four distinct periods are recognizable. First, guided and constantly encouraged by Professor E Donnall Thomas, was the use of an unfractionated mononuclear population derived from multiple sternal and iliac crest aspirations where complications, as in other centres, included rejection and, particularly troublesome, acute as well as chronic GVHD. The second was centred on CsA in association with Professor Jean Borel at Sandoz in Basle, leading to a decrease in the incidence and severity of the latter immunologic pheno...Continue Reading

References

Apr 17, 1975·The New England Journal of Medicine·E ThomasC D Buckner
Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Aug 22, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William J HoganRainer Storb
Jul 15, 2004·Transplantation Proceedings·S ChakrabartiH Waldmann
Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gameda BarendsePeter Jacobs
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jan 18, 2006·Seminars in Hematology·Nelson J Chao, Benny J Chen
Oct 13, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lucille WoodPeter Jacobs

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Citations

Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Fernanda de Paula EduardoLuciana Corrêa
Jun 28, 2011·Expert Opinion on Biological Therapy·Xavier Poiré, Koen van Besien
Feb 13, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gerhard SissolakPeter Jacobs
Feb 2, 2010·Hematology/oncology and Stem Cell Therapy·Lucille WoodPeter Jacobs
Aug 15, 2009·Current Opinion in Hematology·Alois Gratwohl, Helen Baldomero

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