Immunohistochemicaf evidence of parathyroid hormone-related protein in human parathyroid tissue

Endocrine Pathology
P HellmanH Jüppner

Abstract

Immunohistochemical staining for parathyroid hormone-related protein (PTHrp) was investigated on cryosections of 17 normal-sized human parathyroid glands, 47 adenomatous and hyperplastic glands of hypercalcemic patients with primary or uremic hyperparathyroidism, and 5 metastases of parathyroid carcinoma. Utilizing a polyclonal antiserum recognizing aminoterminal PTHrp, approximately two-thirds of the normal and enlarged glands but none of the parathyroid carcinomas demonstrated a conspicuous immunostaining. The extent and intensity of the reactivity varied between the glands even of individual patients. The staining was found in chief and oxyphilic parathyroid cells, and studies of cell suspensions substantiated that the immunoreaction was present also on the surface of the parathyroid cells. Reduced PTHrp expression in the functionally more dedifferentiated parathyroid tissue was suggested by comparison of the normal (i.e., suppressed) and adenomatous parathyroid tissue from the individual patients and by parallel stainings with the monoclonal El1 antibody, which recognizes a calcium sensor involved in the regulation of parathyroid hormone release. The findings substantiate a functional role for PTHrp in euparathyroid and hyp...Continue Reading

References

Feb 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E HendersonD Goltzman
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A A BudayrG J Strewler
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·K IkedaA E Broadus
Apr 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A DanksT J Martin
Jul 1, 1989·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S K AbbasA D Care
Mar 13, 1987·Biochemical and Biophysical Research Communications·C JuhlinL Klareskog
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C JuhlinL Klareskog
Aug 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A F StewartR Baron

❮ Previous
Next ❯

Citations

Nov 1, 1991·World Journal of Surgery·G AkerströmE Gylfe
Mar 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S LundgrenP Hellman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
M P CaulfieldT L Clemens
Nihon rinsho. Japanese journal of clinical medicine
K Watanabe, A Tomita
Nihon rinsho. Japanese journal of clinical medicine
Yoshitaka Kumon, Tetsuro Sugiura
Nihon rinsho. Japanese journal of clinical medicine
K Watanabe, A Tomita
© 2021 Meta ULC. All rights reserved