Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis

The Journal of Pathology
M YasoshimaM E Gershwin

Abstract

We have examined immunohistochemically the expression of adhesion molecules in the micro-environment of portal tracts and their relationship to the expression of the pyruvate dehydrogenase E2 complex (PDC-E2) and HLA-DR in liver biopsy specimens. Ten cases of primary biliary cirrhosis (PBC) and 19 controls were examined, including four cases of extrahepatic biliary obstruction, six of chronic viral hepatitis, and nine normal livers. In PBC, the damaged small bile ducts demonstrated an increased expression of PDC-E2 and an aberrant expression of HLA-DR; about half of these damaged bile ducts also expressed intercellular adhesion molecules (ICAM)-1 and a few expressed vascular adhesion molecule (VCAM)-1. In addition, lymphocyte function-associated antigen (LFA)-1 and very late antigen (VLA)-4 were expressed on infiltrating lymphocytes around these bile ducts. In contrast, in control livers, these alterations in antigen expression on the bile ducts were either not observed or were only focal and weak, when present. These findings suggest that ICAM-1/LFA-1 and also VCAM-1/VLA-4 linkages between the damaged bile ducts and lymphocytes may facilitate antigen-specific reactions such as the presentation of antigens, possibly PDC-E2, to ...Continue Reading

References

Apr 1, 1979·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·O Ohtani
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R VolpesV J Desmet
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H AdamsJ M Neuberger
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R JoplinJ M Neuberger
Mar 1, 1991·Gastroenterology·M E Gershwin, I R Mackay
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R VolpesV J Desmet
Apr 1, 1989·Immunological Reviews·S O WawrykA W Boyd
Aug 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y Nakanuma, M Sasaki
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G YamadaH Nagashima
Jan 1, 1986·Journal of Hepatology·J J Van den OordV J Desmet
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G SteinhoffR Pichlmayr
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y Nakanuma

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Citations

Apr 6, 2006·Clinical & Developmental Immunology·Sabine OerteltM Eric Gershwin
Oct 6, 1997·Journal of Hepatology·G W McCaughan, G A Bishop
Jul 10, 2003·Autoimmunity Reviews·Hiromi IshibashiM Eric Gershwin
Jul 22, 2005·Genes and Immunity·C SelmiM E Gershwin
Nov 21, 1996·The New England Journal of Medicine·M M Kaplan
Jun 6, 2008·World Journal of Gastroenterology : WJG·Ana LleoM-Eric Gershwin
Jun 18, 2009·Seminars in Immunopathology·Andrea T BorchersM Eric Gershwin
Dec 18, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon C AffordBertus Eksteen
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kunio TakegoshiEikichi Okada
Feb 25, 2014·Journal of Hepatology·Peter FickertUNKNOWN International PSC Study Group (IPSCSG)
Oct 22, 2013·Molecular Aspects of Medicine·Marion J PollheimerBruno Stieger
Jan 1, 1997·The Tohoku Journal of Experimental Medicine·M NakadaT Uchikoshi
Sep 8, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·Y NakanumaK Harada
Dec 1, 1996·The Journal of Laboratory and Clinical Medicine·D H Adams
Jan 1, 1996·Toxicologic Pathology·W C Hall, J L Rojko
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raúl J AndradeRamón Hidalgo
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Reynoso-PazM E Gershwin
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HaradaY Nakanuma
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C D HowellW Chen
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathis HeydtmannDavid H Adams
May 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ryo TeradaYasushi Shiratori
Jun 11, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eleonora Patsenker, Felix Stickel
Apr 5, 2017·The Journal of Medical Investigation : JMI·Koichi TsuneyamaHirohisa Ogawa

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