Immunohistochemical analysis of coeliac mucosa following ingestion of oats.

Clinical and Experimental Immunology
U SrinivasanC Feighery

Abstract

There is now considerable clinical evidence that oats do not activate coeliac disease. Nonetheless, a reluctance to include oats in the gluten-free diet remains. Because gluten-induced damage is accompanied by activation of the gastrointestinal immune system, the purpose of this study was to investigate if similar changes were induced by oats ingestion. Small intestinal histological sections from 10 patients who ingested 50 g of oats daily for 3 months were investigated for possible evidence of immune activation. Tissue obtained before and after oats challenge was stained with a series of antibodies directed against the following molecules: human leucocyte antigen D-related (HLA-DR), Ki-67, CD25, CD54 [intercellular adhesion molecule 1 (ICAM-1)] and mast cell tryptase. None of the patients developed clinical or laboratory evidence of adverse effects. The distribution of intestinal HLA-DR expression was not affected by oats ingestion and the crypt epithelium remained unstained. In the pre-oats biopsies, the percentage of Ki-67 positive enterocytes, 29.5 +/- 6.9 [95% confidence interval (CI) 13.9-45.0] did not differ significantly from that found in post-oats biopsies, 41.2 +/- 3.7 (95% CI, 32.8-49.6), P = 0.19, not significant. ...Continue Reading

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Citations

Feb 8, 2011·Nutrition Reviews·Premysl FricJiri Nevoral
Feb 6, 2013·Clinical and Experimental Immunology·S E J CooperC F Feighery
May 10, 2008·European Journal of Gastroenterology & Hepatology·Alberto HernandoEnrique Méndez
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Marco SilanoMassimo De Vincenzi
Aug 17, 2011·Scandinavian Journal of Gastroenterology·Mariantonia MaglioSalvatore Auricchio
Jul 22, 2015·Journal of Pediatric Gastroenterology and Nutrition·Maryam KhalesiHamid R Kianifar
Oct 17, 2019·Frontiers in Pediatrics·Inna Spector CohenRon Shaoul
Sep 1, 2007·Expert Review of Clinical Immunology·Brian M Gill, Daniel A Leffler
Sep 7, 2021·The Journal of Nutrition·Ezra ValidoMarija Glisic

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