Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats

Cancer Letters
R E RichmondA B DeAngelo

Abstract

We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21 ras, p39 c-jun, p55 c-fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.

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Citations

May 31, 2013·Environmental Science and Pollution Research International·Meenu VarshneySudhir K Goel
Dec 18, 1996·Toxicology·A B DeAngeloG R Olson
May 7, 1999·Environmental Health Perspectives·G A Boorman
Nov 14, 1997·Journal of Toxicology and Environmental Health·E W Austin, R J Bull
Nov 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Grace E KisslingGary A Boorman
May 23, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hoffman B M LantumM W Anders

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