Immunohistochemical analysis of extracellular matrix components in synovial sarcoma

The Journal of Pathology
M Guarino, L Christensen

Abstract

Little attention has been paid to the composition of the extracellular matrix in synovial sarcoma, a tumour showing both epithelial and mesenchymal phenotypes. As extracellular matrix participates actively in interactions between epithelial and mesenchymal tissues, further knowledge of the pathogenesis of this tumour may be provided by the study of extracellular matrix components. Therefore, we have analysed the immunohistochemical distribution of type I, III, and IV collagen, fibronectin, laminin and tenascin in four cases of synovial sarcoma. The pattern of immunoreactivity for these molecules varied according to the tissue phenotype of the tumour. Mesenchymal tissue labelled mainly for type I and III interstitial collagen and fibronectin. The epithelial component was surrounded by a laminin and type IV collagen-positive basement membrane, but punctate pericellular reactivity for laminin and type IV collagen was also detected among some mesenchymal cells. Tenascin was strongly expressed in the mesenchymal tissue immediately around epithelial structures and weakly or not at all expressed in the monophasic tumours and in mesenchymal tissue distant from epithelial elements in the biphasic tumours. These results suggest some rese...Continue Reading

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Citations

Nov 1, 1995·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M Guarino, F Giordano
Jul 10, 1999·Pathology, Research and Practice·M GuarinoF Giordano
May 19, 2001·Pathology, Research and Practice·M GuarinoF Giordano
May 20, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H J van der HeideJ A Lemmens
May 20, 1998·International Journal of Cancer. Journal International Du Cancer·M KämäräinenL C Andersson

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