Immunohistochemical analysis of NANOG expression and epithelial-mesenchymal transition in pulmonary sarcomatoid carcinoma

Oncology Letters
Takeshi TamakiShosaku Nomura

Abstract

Pulmonary sarcomatoid carcinomas (PSCs) are defined as a group of poorly differentiated non-small cell lung cancers that demonstrate sarcoma-like differentiation. The mechanism of mesenchymal differentiation in PSC is epithelial-mesenchymal transition (EMT). The expression of homeobox protein NANOG (NANOG), which regulates the pluripotency of embryonic stem cells, is associated with the EMT process. Therefore, the present study aimed to assess the expression level of NANOG and the status of the EMT process in PSC. The data of patients with PSC were retrospectively reviewed and immunohistochemical analyses were performed on patient samples to examine the expression of NANOG and EMT-associated proteins. The comparator group included randomly selected patients with matched clinicopathological characteristics who had pulmonary adenocarcinoma (PA). In the present study, 12 patients with PSC (4 females and 8 males) were enrolled; their median age was 65 years (range, 36-79 years), and the number of patients with stage IB, IIB, IIIA, IIIB and IV disease were 1, 1, 1, 1 and 8, respectively. The immunoreactive score (IRS) for E-cadherin was significantly lower in the PSC group compared with the PA group (P<0.0001), whereas the IRS for v...Continue Reading

References

May 1, 1994·Clinical & Experimental Metastasis·E W ThompsonR B Dickson
Nov 26, 1999·Pathology International·S HaraguchiN Yamanaka
Mar 27, 2002·The American Journal of Surgical Pathology·Sanja DacicSamuel A Yousem
Jul 4, 2002·Cell Biology International·Kwonseop KimElizabeth D Hay
May 20, 2003·The Journal of Pathology·Shigeki SekineSetsuo Hirohashi
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Silvestre VicentLuis M Montuenga
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jin-Yuan ShihPan-Chyr Yang
Aug 31, 2006·Virchows Archiv : an International Journal of Pathology·Markus BlaukovitschHelmut H Popper
Jan 2, 2007·Biochemical and Biophysical Research Communications·Hyun-Jin DoJae-Hwan Kim
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Jan 7, 2009·International Journal of Surgical Pathology·Giuseppe PelosiJuan Rosai
Apr 8, 2009·Stem Cells·David F ChangCarolyn Lutzko
Dec 23, 2009·Cancer Biology & Therapy·Hui-Min MengJianming Li
Jan 27, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yongmiao PanHuaizeng Chen
Jun 12, 2012·The American Journal of Pathology·Ting-Ting GuPeng-Sheng Zheng
Sep 11, 2013·Surgical Oncology·Yaming DuTianyi Wang

❮ Previous
Next ❯

Citations

Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong Woo ParkJeung-Whan Han
Mar 5, 2021·International Journal of Cancer. Journal International Du Cancer·Toru NarusakaToshiyoshi Fujiwara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.