Immunohistochemical analysis of RHAMM expression in normal and neoplastic human tissues: a cell cycle protein with distinctive expression in mitotic cells and testicular germ cells

Oncotarget
Yao-Tseng ChenYi-Chieh Nancy Du

Abstract

Expression of Receptor for Hyaluronic Acid Mediated Motility (RHAMM) increases cellular motility and RHAMM overexpression promotes invasive phenotype and metastasis of cancer cells. RHAMM has been suggested as a biomarker for poor prognosis in several tumor types, including lung, breast, colorectal, gastric, pancreatic ductal, and ovarian cancers. RNA studies showed restricted RHAMM expression in normal tissues, but its protein expression data in tissues were limited. In light of its potential as a prognostic marker and a therapeutic target, we performed immunohistochemical analysis to systematically characterize RHAMM expression in normal and neoplastic human tissues. Among 29 normal adult tissues, RHAMM protein showed restricted expression and was observed in the thymus, lymph node/tonsil, small intestine, colon, skin, bone marrow, placenta, and testis. The cellular distribution patterns of RHAMM in these normal tissues were consistent with RHAMM being a G2/M cell cycle protein, and this was further supported in comparison to the expression of cyclin B2, another G2/M protein. However, unlike the subcellular localization of cyclin B2, RHAMM decorated mitotic spindles in both anaphase and metaphase. RHAMM expression in tumor ti...Continue Reading

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Citations

Dec 26, 2018·Molecular Carcinogenesis·Huaibiao LiAspasia Ploubidou
May 11, 2019·Molecular Cancer·Soyoung ChoiYi-Chieh Nancy Du
Sep 23, 2020·Cardiovascular Engineering and Technology·Sheldon WeinbaumJohn M Tarbell
Jul 6, 2019·Seminars in Cancer Biology·Spyros S SkandalisParaskevi Heldin
Jul 19, 2019·Seminars in Cancer Biology·Ilaria CaonAlberto Passi
Feb 4, 2021·Bioengineering & Translational Medicine·Daniel C PanSamir Mitragotri
May 25, 2021·The Journal of Investigative Dermatology·Adrienne K Joseph, Benjamin F Chong
Aug 21, 2019·Journal of Proteome Research·Charles PineauCecilia Lindskog

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