PMID: 2510792Jan 1, 1989Paper

Immunohistochemical and biochemical analysis of the development of the noradrenaline- and adrenaline-storing cells in the adrenal medulla of the rat and pig

Archives of Histology and Cytology
A A VerhofstadB Colenbrander

Abstract

The development of the noradrenaline (NA)- and adrenaline (A)-storing cells was examined in the adrenal gland of pre- and postnatal rats and pigs. Cryostat sections were immunostained with antibodies to NA and A. Amine levels were estimated in homogenates of adrenals by ion-pair reversed-phase liquid chromatography with electrochemical detection. 1. In adult animals separate NA- and A-storing cells were found. In the rat A-cells comprised about 80% of the parenchyma of the adrenal medulla. NA-cells, the remaining 20%, were randomly arranged in clusters. In the pig, in contrast, the A- and NA-storing cells were equally distributed, with spherical clusters of NA-cells were surrounded by A-cells. 2. In the earliest developmental stages examined (16th day of gestation in the rat, and 42nd day in the pig) the adrenals only contained NA-immunoreactive cells. In the rat separate NA- and A-storing cells were first noticed 2 or 3 days after birth, whereas in the pig separated cells were already present at the 56th prenatal day (full term at 114th day). 3. In both rat and pig adrenals dopamine (DA), NA and A increased in amount rapidly during development. In the rat this change mainly took place after birth (an increase of 13 times from ...Continue Reading

Citations

Mar 17, 2004·Archives of Biochemistry and Biophysics·O L ZaikaE A Lukyanetz
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·K TornøeJ J Holst

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