Immunohistochemical and fine structural characterization of primary carcinoid tumors of the larynx

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
R Dieler, J Dämmrich

Abstract

Carcinoid tumors belong to the group of neuroendocrine tumors of epithelial origin, i.e., neuroendocrine carcinomas. These neoplasms usually occur in the gastrointestinal tract or bronchial system but are very rare neoplasms in the larynx. Since carcinoid tumors in this latter site may appear to be undifferentiated by light microscopy, they may possibly be misinterpreted and their neuroendocrine characteristics may remain unrecognized. Using immunohistochemical methods, three carcinoid tumors were studied and showed positive immunostaining for markers of epithelial origin (cytokeratins, epithelial membrane antigen, carcino-embryonic antigen) and, in particular, for markers of neuroendocrine differentiation (chromogranin, synaptophysin, neuron-specific enolase). All tumors expressed calcitonin-, serotonin- and adrenocorticotropic-hormone-like immunoreactivity. In contrast, three poorly differentiated squamous cell carcinomas showed positive immunostaining for epithelial markers but did not show any immunoreactivity with markers of endocrine characteristics. Fine structurally, carcinoid tumor cells contained neurosecretory-type granules scattered throughout the cytoplasm. The present study demonstrated that (1) carcinoid tumors o...Continue Reading

Citations

Jun 10, 2008·Annales de pathologie·Mohamed OukabliFranck Fetissof
Jun 19, 2018·The Journal of Laryngology and Otology·F LópezA Ferlito
Jan 7, 1999·The Journal of Laryngology and Otology·A FerlitoC M Milroy
Dec 16, 2004·World Journal of Surgery·Irvin M ModlinMark Kidd
Mar 25, 2017·Advances in Anatomic Pathology·Jennifer L HuntAntonio Cardesa
Jul 1, 2006·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·K Salil KumarC V Vivek

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