Immunohistochemical and genetic analysis of osteoclastic giant cell tumor of the pancreas

Pancreas
Zdenek LukásBoris Habanec

Abstract

Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, as well as other components of the tumor, and lacked any signs of epithelial differentiation in both patients. The nonepithelial nature of both components in the osteoclastic giant cell tumors presented may be associated with a better prognosis, which corresponds to the previous reports of similar neoplasms. A positive immunoreactivity to neuron-specific enolase was recorded in patient 2. The presence of CD68 in osteoclastic giant cells proved their histiocytic nature. Both components of the tumors showed a negative immunoreactivity to desmin and only a scattered reactivity to smooth muscle cell actin, typical markers of myofibroblastic differentiation. Mutation analysis of the tumor revealed the wild state of both p53 and K-ras oncogenes in both patients. A positive immunoreactivity for p53 in PCs of both osteoclastic giant cell tumors was recorded, whereas osteoclastic giant cells did not express this protein. The...Continue Reading

References

Jan 1, 1992·Gastroenterology·N R LemoineG Klöppel
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H P FischerJ Kracht
Feb 2, 1999·Experimental Cell Research·A L Gartel, A L Tyner
May 26, 1999·The Journal of Pathology·C Prives, P A Hall
Apr 11, 2000·Molecular and Cellular Biology·M AshcroftK H Vousden
Dec 21, 2002·International Journal of Clinical Oncology·Manabu ShiozawaYoshiaki Inayama

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Citations

Apr 16, 2009·Journal of Hepato-biliary-pancreatic Surgery·Yoshiki NaitoHirohisa Yano
Nov 29, 2007·The American Journal of Surgical Pathology·Frank BergmannPeter Schirmacher
Aug 1, 2010·Clinical Journal of Gastroenterology·Yasuhiro TogawaAkihiro Toyoda
Jun 20, 2012·Journal of Surgical Oncology·Michelle D ReidN Volkan Adsay
Mar 19, 2014·International Journal of Surgery Case Reports·Wudneh M TemesgenSharmila Dissanaike
Mar 23, 2021·Frontiers in Oncology·Pieter DemetterLaurine Verset
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Stephen A GellerRanda Alsabeh
Feb 27, 2021·Journal of Pediatric Hematology/oncology·Sara DonigianRebecca O Clark

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