Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Eunhyang ParkNam Hoon Cho

Abstract

Invasive stratified mucin-producing carcinoma (ISMC) is a recently described entity of human papillomavirus (HPV)-associated endocervical adenocarcinoma with phenotypic plasticity and aggressive clinical behavior. To identify the cell of origin of ISMC, we investigated the immunohistochemical expression of cervical epithelial cell markers (CK7, PAX8, CK5/6, p63, and CK17), stemness markers (ALDH1 and Nanog), and epithelial-mesenchymal transition (EMT) markers (Snail, Twist, and E-cadherin) in 10 pure and mixed type ISMCs with at least 10% of ISMC component in the entire tumor, seven usual type endocervical adenocarcinomas (UEAs), and seven squamous cell carcinomas (SCCs). In addition, targeted sequencing was performed in 10 ISMCs. ISMC was significantly associated with larger tumor size (p = 0.011), more frequent lymphovascular invasion and lymph node metastasis (p < 0.001), higher FIGO stage (p = 0.022), and a tendency for worse clinical outcomes (p = 0.056) compared to other HPV-associated subtypes. ISMC showed negative or borderline positivity for PAX8, CK5/6, and p63, which were distinct from UEA and SCC (p < 0.01). Compared to UEA and SCC, ISMC showed higher expression for ALDH1 (p = 0.119 for UEA and p = 0.009 for SCC), S...Continue Reading

References

Oct 7, 2000·The American Journal of Surgical Pathology·J J ParkC P Crum
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Carmen BirchmeierGeorge F Vande Woude
Dec 21, 2005·The Journal of Cell Biology·Hanna Y IrieJoan S Brugge
Mar 28, 2006·Cell·Michael F Clarke, Margaret Fuller
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Terence K LeeSheung Tat Fan
Oct 11, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ShibataF Kikkawa
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
May 7, 2009·Archives of Pathology & Laboratory Medicine·Kay J Park, Robert A Soslow
Mar 9, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Badal C RoyJun Yokota
Feb 15, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ayhan OzcanLuan D Truong
May 10, 2011·The American Journal of Surgical Pathology·Anna R LauryMichelle S Hirsch
May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna YemelyanovaRobert J Kurman
Dec 16, 2011·Journal of Clinical Microbiology·Heejung AnTaisun Kim
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael HerfsChristopher P Crum
Feb 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanyan YangXiuying Li
May 16, 2014·The Journal of International Medical Research·Tingting YaoZhongqiu Lin
Jun 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kassaporn DuangkumphaPuangrat Yongvanit
Jan 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Youzhi LiChiang J Li
May 12, 2015·The Lancet Oncology·Cezary CybulskiUNKNOWN Polish Hereditary Breast Cancer Consortium
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Feb 7, 2017·Annals of Translational Medicine·Hye-Min Jeon, Jeongwu Lee
May 22, 2018·PLoS Genetics·Yi HaoDavid Wotton
Jun 1, 2018·The American Journal of Surgical Pathology·Simona StolnicuRobert A Soslow
Aug 16, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Soo-Jeong ChoSam S Yoon
Sep 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simona StolnicuRobert A Soslow
Jan 5, 2019·BMC Cancer·Ezequiel MonferrerRosa Noguera
Jul 17, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Swati GargMarjan Rouzbahman
Nov 24, 2019·Gynecologic Oncology·Sou HiroseHiroshi Yoshida
Apr 3, 2020·The American Journal of Surgical Pathology·Simona StolnicuKay J Park
Jul 10, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eunhyang ParkNam Hoon Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.