Immunohistochemical and genetic profiles of endometrioid endometrial carcinoma arising from atrophic endometrium

Gynecologic Oncology
Yvette P GeelsLeon F A G Massuger

Abstract

Endometrial carcinomas are divided into type I endometrioid endometrial carcinomas (EECs), thought to arise from hyperplastic endometrium, and type II nonendometrioid endometrial carcinomas, thought to arise from atrophic endometrium. However, a minority (20%) of EECs have atrophic background endometrium, which was shown to be a marker of a worse prognosis. This study compares the immunohistochemical and genetic profiles of this possible third type to that of the known two types. 43 patients with grade 1 EEC and hyperplastic background endometrium (type I), 43 patients with grade 1 EEC and atrophic background endometrium (type III) and 21 patients with serous carcinoma (type II) were included (n=107). Tissue microarrays of tumor samples were immunohistochemically stained for PTEN, L1CAM, ER, PR, p53, MLH1, PMS2, β-catenin, E-cadherin and MIB1. The BRAF, KRAS, and PIK3CA genes were analyzed for mutations. A significantly higher expression of ER and PR, and a lower expression of L1CAM, p53 and MLH1 were found in type I and III compared to type II carcinomas. Expression of E-cadherin was significantly reduced in type III compared to type I carcinomas. Mutation analysis showed significantly less mutations of KRAS in type III compar...Continue Reading

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Citations

Feb 17, 2017·Carcinogenesis·Louis J M van der PuttenLeon F A G Massuger
Sep 17, 2019·International Journal of Cancer. Journal International Du Cancer·Casper ReijnenJohanna M A Pijnenborg
Aug 30, 2018·Molecular and Clinical Oncology·Naoki OganeMasanori Yasuda
Feb 14, 2019·Der Pathologe·L-C HornUNKNOWN Kommission zur Erstellung der S3-Leitlinie „Diagnostik, Therapie und Nachsorge der Patientinnen mit Endometriumkarzinom“
Mar 12, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jie ShenYun-Xiao Zhou

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