PMID: 2123893Nov 1, 1990Paper

Immunohistochemical and ultrastructural study of histiocytosis X and non-X histiocytoses

Journal of the American Academy of Dermatology
M FartaschO P Hornstein

Abstract

The diagnostic reliability of ultrastructural and immunohistochemical examinations on routinely processed biopsy specimens of cutaneous histiocytic proliferations (histiocytosis X, n = 7; juvenile xanthogranuloma, n = 4; necrobiotic xanthogranuloma, n = 2; traumatic granuloma of the tongue, n = 1) was evaluated. S-100 protein, peanut agglutinin, and the antibody Mac-387 were used as markers for histiocytes. The frequency of Birbeck granule-containing cells in seven histiocytosis X lesions did not correspond with the number of S-100+ or peanut agglutinin+ cells. All neoplastic histiocytosis X cells were positive for S-100 protein and peanut agglutinin but were negative for Mac-387. Histiocytes of juvenile xanthogranuloma, necrobiotic xanthogranuloma, and traumatic granuloma were strongly positive for Mac-387 but were negative for S-100 protein and peanut agglutinin, except for the peanut agglutinin-reactive Touton giant cells. Mac-387 reliably differentiates histiocytic proliferations of the monocyte/macrophage system from those of the dendritic cell system. For the diagnosis of histiocytosis X, both S-100 protein and peanut agglutinin positivity in histiocytes is as reliable as ultrastructural demonstration of Birbeck granules.

References

Apr 1, 1988·Journal of the American Academy of Dermatology·M Kashihara-SawamiS Imamura
Jun 1, 1987·Journal of Cutaneous Pathology·N VigneswaranK P Peters
Apr 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, H J Ree

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Citations

Jan 1, 1996·Pathology Oncology Research : POR·Ferenc KôhalmiJózsef Tímár
Mar 1, 1997·Journal of the American Academy of Dermatology·A Hernandez-MartinN B Esterly
Jun 10, 2000·The British Journal of Dermatology·P GottlöberM Kerscher
Nov 17, 1999·Clinical and Experimental Dermatology·S H IbbotsonN J Reynolds
May 1, 1996·The American Journal of Surgical Pathology·P H LiebermanM Sperber
Aug 15, 1998·Pathology International·H Y HuangW J Chen
Mar 1, 1993·Pediatric Dermatology·A L ClaudyS Boucheron
Aug 1, 1994·Journal of the American Academy of Dermatology·S GoerdtG Kolde
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A W BarrettD M Williams
May 1, 1992·Journal of the American Academy of Dermatology·B S DarwinE A Olsen
Oct 19, 2004·International Journal of Pediatric Otorhinolaryngology·Ana Nusa NaimanPatrick Froehlich
Aug 1, 1995·Journal of Cutaneous Pathology·O P SangüezaJ H Beckstead
Oct 1, 1995·Journal of Cutaneous Pathology·E Sánchez YusP Valle
Jan 1, 1992·The British Journal of Dermatology·G Kolde, G Bonsmann
Apr 29, 1998·Journal of Cutaneous Pathology·M M Tomaszewski, G P Lupton
Jan 24, 2007·Ophthalmic Plastic and Reconstructive Surgery·Zeynel A Karcioglu
Feb 1, 1992·The British Journal of Dermatology·G I Stables, R M Mackie
Nov 1, 1993·The Journal of Laryngology and Otology·J W NicolK MacKenzie
Sep 1, 1999·Seminars in Cutaneous Medicine and Surgery·M W Chang
Nov 1, 1996·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·D R Benjamin

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