Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands

Oral Oncology
Suzana O Machado de SousaVera Cavalcanti de Araújo

Abstract

Basal cell adenoma is a benign epithelial neoplasm with a uniform histologic appearance dominated by basaloid cells. Those cells may be distributed in various arrangements as solid, trabecular, tubular and membranous. Canalicular adenoma is also a benign neoplasm composed by columnar cells arranged in branching and interconnecting cords of single or double cell thick rows. There is some disagreement among investigators about whether canalicular adenoma should be included within the basal cell adenoma histologic spectrum. In the present study we compared the expression of cytokeratins (CK), vimentin and muscle-specific actin, utilizing immunohistochemical technique, in three cases diagnosed as basal cell adenomas predominantly of the solid type, and three cases of canalicular adenomas. The results obtained showed a distinct immunoprofile for both neoplasms. Solid areas of basal cell adenomas did not stain for any of the tested antibodies; only when there was tubular differentiation, those structures expressed CKs 7, 8, 14, and 19 in luminal cells and vimentin in non-luminal cells. On the other hand, canalicular adenomas strongly expressed CKs 7 and 13. The panel of antibodies utilized supports the separation of the two entities.

References

Mar 1, 1976·Cancer·W JaoM A Swerdlow
Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·V C de Araújo, N S de Araújo
Feb 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·J G Guccion, R S Redman
Feb 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·T D DaleyM S Smout
Dec 1, 1983·Oral Surgery, Oral Medicine, and Oral Pathology·D G Gardner, T D Daley
Sep 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M D McMillanA C Smillie
Jan 1, 1996·European Journal of Cancer. Part B, Oral Oncology·V C de Araújo, S O de Sousa
Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·G Seifert, K Donath
Dec 10, 1998·Annals of Diagnostic Pathology·P SuarezP G Stimson
May 23, 2012·Gerodontology·Christiano Oliveira-SantosAlberto Consolaro

❮ Previous
Next ❯

Citations

Oct 23, 2003·Annals of Diagnostic Pathology·Cristiane FuruseVera Cavalcanti de Araújo
Jun 18, 2005·The Bulletin of Tokyo Dental College·Kenichi MatsuzakaTakashi Inoue
Dec 1, 2011·Surgical Pathology Clinics·Raja R Seethala, E Leon Barnes
Aug 2, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·E R FregnaniP A Vargas
Mar 8, 2011·Diagnostic Cytopathology·Nalini GuptaArvind Rajwanshi
May 4, 2004·Auris, Nasus, Larynx·Lélia Maria Guedes QueirozCarlos César Formiga Ramos
Aug 22, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Angela J YoonDavid J Zegarelli
Dec 12, 2013·Gerodontology·Stefano SivolellaEdoardo Stellini
May 20, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Priya Anil BhagdeJayanti G Humbe
Jan 30, 2014·Brazilian Dental Journal·Carla Silva SiqueiraSuzana Cantanhede Orsini Machado de Sousa
Jul 13, 2017·Orbit·Mansoreh Jamshidian-TehraniMasoud Aghsaei Fard
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Gianfranco FaviaRosario Serpico
Mar 1, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Anna TroshkinaLarry L Myers
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nikolaos G NikitakisOlga B Ioffe
May 20, 2017·Craniomaxillofacial Trauma & Reconstruction·Velavan KrishnanKumaravel Subramaniam
Sep 18, 2021·BMJ Case Reports·Priya K NairMahija Janardhanan
Oct 13, 2021·Laryngo- rhino- otologie·Marlene M SpethAlejandra Magagna-Poveda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Diagnostic Pathology
Cristiane FuruseVera Cavalcanti de Araújo
Oral Surgery, Oral Medicine, and Oral Pathology
J G Guccion, R S Redman
Oral Surgery, Oral Medicine, and Oral Pathology
T D DaleyM S Smout
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M D McMillanA C Smillie
Oral Surgery, Oral Medicine, and Oral Pathology
J A Ferreiro
© 2021 Meta ULC. All rights reserved