Abstract
Non-dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory response triggered through prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. NF-κB activation as a result of the inflammatory response has been shown in NDBE, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for NF-κB activation along the oesophageal metaplasia-dysplasia-adenocarcinoma sequence. Survivin is an NF-κB-inducible anti-apoptotic protein, and Bcl3 is a negative regulator of NF-κB. There was progressive upregulation of Survivin expression along the oesophageal metaplasia-dysplasia-adenocarcinoma sequence. Bcl3 expression was upregulated in non-dysplastic Barrett's oesophagus, low-grade, high-grade dysplasia and oesophageal adenocarcinoma when compared to squamous group. The study shows the differential expression of Bcl3 between the squamous and Barrett's stage, suggesting that Bcl3 could be a surrogate marker for early event involving constitutive NF-κB activation. In addition, the study suggests that NF-κB activation may infer resistance to apoptosis ...Continue Reading
References
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Mar 14, 2000·Oncogene·P C CogswellA S Baldwin
Dec 31, 2003·The Journal of Experimental Medicine·Zheng XingAstar Winoto
Mar 17, 2004·Annals of Surgery·Mohamed M M Abdel-LatifJohn V Reynolds
Apr 23, 2004·Trends in Biochemical Sciences·Yumi Yamamoto, Richard B Gaynor
Oct 14, 2004·The Journal of Pathology·Judit PallaresXavier Matias-Guiu
Jan 20, 2005·Journal of the National Cancer Institute·Heiko Pohl, H Gilbert Welch
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Hirochika KawakamiNaoki Mori
Jun 3, 2005·The American Journal of Gastroenterology·J M O'RiordanJ V Reynolds
Sep 3, 2008·Cellular & Molecular Immunology·Jianxun SongRizwanul Haque
Jan 17, 2009·Cancer Research·Kathy Hormi-CarverRhonda F Souza
Sep 8, 2010·Biochimica Et Biophysica Acta·Kewei WangAi-Xuan Holterman
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Sagar S GarudField F Willingham
Oct 18, 2011·Journal of Neuroinflammation·Miles HerkenhamSamuel J Listwak
May 15, 2012·Oncogene·K AhlqvistR Massoumi
Apr 8, 2015·Molecular Medicine Reports·Ying Li, Juanjuan Ding
Sep 26, 2015·Oncoimmunology·Neil L BerinsteinMarc Mansour
Oct 10, 2015·Oncotarget·Paul MakArthur M Mercurio
Mar 5, 2016·Oncotarget·Niamh E BuckleyPaul Mullan
Nov 9, 2016·OncoTargets and Therapy·Hu ZhaoYuling Liu
Apr 30, 2017·Nature Communications·Sonja ReißigNadine Hövelmeyer