Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer

Oncotarget
Rui-Yun ChenChia-Hung Kao

Abstract

This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx. VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL. Immunohistochemical biomarkers in pretreatment biopsy specimens from 60 patients with p16-negative cancer were analyzed using tissue microarrays. Computed tomography (CT)-based and biological tumor volumes were retrieved through fluorodeoxyglucose positron emission tomography-CT. Correlations of cause-specific, disease-free, and primary relapse-free survival with volumetric parameters and the immunohistochemical biomarker score were investigated. For patients with p16-negative pharyngeal cancer receiving radiotherapy, treatment outcomes can be stratified by VEGF and GLUT1 expression and CT-based gross tumor volume.

References

May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D SmithB G Haffty
Feb 22, 2002·Cancer·Christian CoutureAndré Fortin
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Dec 4, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Dirk Vordermark, J Martin Brown
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Jul 27, 2005·Journal of Cancer Research and Clinical Oncology·Panayiotis A KyzasNiki J Agnantis
Jan 17, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Im Il NaYoon Sang Shim
Jun 5, 2007·International Journal of Cancer. Journal International Du Cancer·Camille C R Ragin, Emanuela Taioli
Sep 25, 2007·The Laryngoscope·Joel A ErnsterMichael Mathews
Dec 7, 2007·Japanese Journal of Clinical Oncology·Seok Jin KimEgbert Oosterwijk
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bhavna KumarThomas E Carey
Nov 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pernille LassenUNKNOWN Danish Head and Neck Cancer Group (DAHANCA)
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Jun 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Angela HongBarbara Rose
Oct 16, 2010·Head & Neck·Benjamin LallemantJean-Paul Brouillet
Feb 9, 2011·International Journal of Radiation Oncology, Biology, Physics·Nigel BrocktonAnthony Magliocco
May 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maura L GillisonK Kian Ang
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Tomohiro YamadaTetsuya Yamamoto
Dec 18, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan AkervallBin Teh
Aug 6, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liam MastersonPeter K C Goon
Oct 21, 2016·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Y-C LinC-H Kao

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BETA
biopsy

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Advantage Workstation Volume Share
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