Immunohistochemical BRAF V600E Expression and Intratumor BRAF V600E Heterogeneity in Acral Melanoma: Implication in Melanoma-Specific Survival

Journal of Clinical Medicine
Takamichi ItoMasutaka Furue

Abstract

Acral melanoma, a distinct form of cutaneous melanoma originating in the glabrous skin of the palms, soles, and nail beds, has a different genetic background from other subtypes of cutaneous melanoma. The roles of oncogenic BRAF mutations of acral melanoma in pathogenesis and patient outcomes have not been fully elucidated. We retrieved a total of 112 patients with primary acral melanoma and checked their BRAF V600E status using immunohistochemical staining of VE1 antibody. Among these cases, 21 acral melanoma samples (18.8%) showed positive BRAF V600E staining, and of those, 11 samples (9.8%) showed a heterogeneous staining pattern, with a mixture of VE1-positive and VE1-negative cells. BRAF V600E positivity was significantly associated with thicker melanoma (p = 0.0015). There was no significant difference in clinicopathological factors between homogeneous and heterogeneous VE1-positive acral melanoma. Both patients with BRAF V600E-positive acral melanoma and those with heterogeneous BRAF V600E had significantly shorter melanoma-specific survival than those with BRAF V600E-negative melanoma in Kaplan-Meier analysis (p = 0.0283 and p = 0.0065, respectively). These findings provide novel insights into the pathobiology of acral ...Continue Reading

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Citations

Jul 28, 2020·Journal of Clinical Medicine·Takamichi ItoMasutaka Furue
Dec 19, 2020·Japanese Journal of Clinical Oncology·Yukiko Kiniwa, Ryuhei Okuyama
Jan 23, 2021·International Journal of Molecular Sciences·Yuka TanakaTakamichi Ito
Feb 10, 2021·Current Treatment Options in Oncology·Takamichi ItoMasutaka Furue
Jul 3, 2021·The Journal of Pathology. Clinical Research·Sara S BernardesPatricia A Possik

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism
JMP Pro
GraphPad

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