Immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Sebastián RodríguezHiroyuki Nakayama

Abstract

One of the most important models for analyzing the pathomorphological aspects of Parkinson's disease (PD) is the 6-hydroxydopamine (6-OHDA) model where lesions of the nigrostriatal axis are observed when 6-OHDA is intrastriatally injected. Despite the widespread use in rats, only few studies about the toxicity of 6-OHDA have been carried out in other species. In the present study, we evaluated for the first time the effects of a single intrastriatal injection of 6-OHDA (20 μg dissolved in 2 μl of vehicle) in the young-adult golden hamster (GH). Significant decreases in tyrosine hydroxylase (TH)-positive area and dopamine transporter (DAT)-positive area were found in the ipsilateral striatum 3 days after the injection. These decreases in immunoreactivity continued for 7 days and a recovery trend was found at days 15 and 21 post injection. On the other hand, no effect of injection was found on the contralateral side. In the substantia nigra pars compacta (SNpc), a significant decrease in the number of TH-positive cells appeared one week after the injection with the peak in the loss of TH-positive immunoreactivity being recorded two weeks post-injection. On the basis of the results herein reported, we believe that the GH is a suit...Continue Reading

References

Jan 1, 1975·Biochemical Pharmacology·C Sachs, G Jonsson
Oct 10, 1975·Life Sciences·D L GarverJ W Maas
Aug 14, 1989·Brain Research·D A PereseK S Bankiewicz
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Jan 1, 1980·Annual Review of Neuroscience·G Jonsson
Aug 21, 1995·The Journal of Comparative Neurology·C FreedM J Kuhar
Jun 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·B S JeonR E Burke
Sep 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·V Jackson-LewisS Przedborski
Aug 15, 1998·Biochemical and Biophysical Research Communications·Y MitsumotoN Koga
Oct 31, 2002·Nature Neuroscience·Ted M Dawson, Valina L Dawson
Jan 22, 2003·The European Journal of Neuroscience·Kati KühnChristine C Stichel
Apr 1, 2003·Annals of Neurology·Stephane Hunot, E C Hirsch
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Jun 1, 2005·Behavioural Brain Research·Ruxandra IancuGesine Paul
Jul 29, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sebastián RodríguezHiroyuki Nakayama

❮ Previous
Next ❯

Citations

Sep 1, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hui LianZhi-Yong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.