PMID: 11604161Oct 18, 2001Paper

Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS)

Veterinary Immunology and Immunopathology
G SarliP S Marcato

Abstract

The superficial inguinal lymph nodes of 10 piglets which had died spontaneously of post-weaning multisystemic wasting syndrome (PMWS), in which the porcine circovirus type II (PCV-II) genome was revealed by PCR, were submitted to immunohistochemical investigation for CD4, CD8, IgM, MAC387, S-100 protein, vimentin and F-VIII-RA and compared with three normal cases. The lymph node reaction was graded as initial, intermediate and end stage according to histological criteria. In the initial and intermediate stages, absence of follicles and depletion of lymphocytes were evident. Associated with this was a reduction in numbers of interfollicular dendritic cells and interdigitating cells and a reduction/absence of B cells and mainly CD4+ T lymphocytes. In the end stage the reduced expression of high endothelial venules and the prevalence of the stromal component of the lymph node was prominent, as well as the above changes. It is concluded that more than one mechanism is involved in the immunosuppressive ability of PCV-II: reduction of the antigen presenting ability and reduction of B cells and CD4+ T cell function.

References

Jan 1, 1982·Veterinary Immunology and Immunopathology·R M Binns
Oct 1, 1994·Veterinary Immunology and Immunopathology·M D PescovitzW C Davis
Oct 1, 1994·Veterinary Immunology and Immunopathology·A SaalmüllerH Salmon
Jan 1, 1996·Veterinary Immunology and Immunopathology·F McNeillyJ Pollock
Jan 30, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J EllisF McNeilly

❮ Previous
Next ❯

Citations

Jan 1, 2004·Veterinary Immunology and Immunopathology·L MandrioliP S Marcato
Jan 27, 2004·Veterinary Microbiology·Joaquim SegalésEnric Mateu
May 6, 2003·Veterinary Immunology and Immunopathology·J NielsenK C McCullough
Jan 7, 2003·Viral Immunology·Steven KrakowkaGordon Allan
Nov 2, 2005·BMC Veterinary Research·Matti KiupelSuresh K Mittal
Oct 29, 2002·The Veterinary Quarterly·J Segalés, M Domingo
Dec 20, 2011·Virus Research·Laila Darwich, Enric Mateu
Aug 17, 2010·Journal of Comparative Pathology·I Galindo-CardielJ Segalés
May 11, 2010·Veterinary Immunology and Immunopathology·T KekarainenG M Allan
Aug 30, 2014·Virology·Rupali WaliaMarkus Czub
Jul 17, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A NúñezL Carrasco
Jun 14, 2012·Veterinary Pathology·T Opriessnig, I Langohr
Jun 14, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Steven KrakowkaGordon Allan
Sep 3, 2008·Animal Health Research Reviews·Sheela Ramamoorthy, Xiang-Jin Meng
Jan 31, 2017·Archives of Virology·Giuseppe MarruchellaCiriaco Ligios

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.