Immunohistochemical characteristics of intramural leiomyomata that enlarge during controlled ovarian hyperstimulation for in vitro fertilization

Gynecologic and Obstetric Investigation
Hulusi B ZeynelogluSertac Batioglu

Abstract

This study aimed to determine the immunohistochemical characteristics of intramural leiomyomata that enlarged during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). For this retrospective case-control clinical study and immunohistochemical analysis, 5 patients with enlarged intramural leiomyomata during COH for IVF, who had undergone myomectomy immediately after a failed IVF cycle, were recruited retrospectively. Fifteen consecutive patients who had had myomectomy for intramural leiomyomata <5 cm, but had never undergone any infertility treatment, served as the control group. Histological examinations and immunohistochemical staining with proliferating cell nuclear antigen (PCNA), transforming growth factor-beta (TGF-beta) and fibronectin were performed on all specimens taken from the study and control groups. The main outcome measures were defined as histological and immunohistochemical scores. Hematoxylin and eosin as well as PCNA staining showed increased mitotic index, cellularity and proliferation index in these growing leiomyomata (study group). There were neither increased mitoses nor cellularity in the leiomyomata of the control group, while PCNA, TGF-beta and fibronectin scores in the study ...Continue Reading

References

Jan 1, 1992·American Journal of Clinical Pathology·R A Prayson, W R Hart
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I SuzukaT Moriuchi
Nov 1, 1970·Journal of Clinical Pathology·L Deligdish, M Loewenthal
Jan 1, 1983·Annual Review of Biochemistry·K M Yamada
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·E LeviI Vlodavsky
Jul 1, 1996·Human Reproduction Update·E A Stewart, R A Nowak
Dec 28, 1999·Microbes and Infection·M H Branton, J B Kopp
Oct 19, 2000·Environmental Health Perspectives·D L Healy
Jul 15, 2003·Current Opinion in Obstetrics & Gynecology·Eric S Surrey

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Citations

Nov 18, 2017·International Journal of Molecular Sciences·Michał CiebieraGrzegorz Jakiel

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