PMID: 7539445Feb 1, 1995Paper

Immunohistochemical characterization of human endometrial microvascular basement membrane components during the normal menstrual cycle

Human Reproduction
F D KellyP A Rogers

Abstract

The expression of three basement membrane components [collagen IV (CIV), laminin and heparan sulphate proteoglycan (HSPG)] and platelet endothelial cell adhesion molecule (PECAM) were examined by immunohistochemistry in cryostat sections of normal human endometrium. Alkaline phosphatase (ALP) was detected using enzyme histochemistry. Endometrial biopsies from the menstrual (n = 4), mid-late proliferative (n = 5), early-mid secretory (n = 5) and late secretory (n = 5) stages were collected from women with a normal menstrual cycle. At all four stages of the menstrual cycle, CIV, laminin and HSPG were expressed on basement membranes of both vessels and glands whilst PECAM expression was localized specifically to endothelial cells. A similar number of vessels/mm2 stained for CIV and laminin, as well as for PECAM at each stage of the menstrual cycle, demonstrating that all vessels in endometrium stain for these two basement membrane components. By contrast, the number of vessels/mm2 that stained positively for HSPG and ALP was significantly lower, averaging approximately 55% of the total that stained positively for PECAM, CIV and laminin. During the menstrual stage, HSPG staining intensity remained strong in glandular basement membr...Continue Reading

Citations

Oct 8, 2005·Angiogenesis·Oliver P Milling Smith, Hilary O D Critchley
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley
Apr 25, 2017·Journal of Cellular Biochemistry·Mostafa Peyvandi KarizbodaghHamed Mirzaei
Aug 14, 2019·Oncology Letters·Michelle Van SinderenEvdokia Dimitriadis
Aug 21, 2013·The Cochrane Database of Systematic Reviews·Muhammad A AkhtarSiobhan Quenby

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