Immunohistochemical characterization of keratin expression in clear cell acanthoma

The British Journal of Dermatology
T Ohnishi, S Watanabe

Abstract

The nature of clear cell acanthoma has not been clarified, although many hypotheses have been proposed, including a benign neoplasm derived from epidermis or the acrosyringium, or a non-specific dermatosis. In this study, seven cases of clear cell acanthoma were analysed by immunohistochemical techniques, using various monoclonal antikeratin antibodies, and antibodies against filaggrin, involucrin and epithelial membrane antigen. Different immunoreactivities were noted between clear cell acanthoma and a normal eccrine gland, including the acrosyringium. Immunoreactivities of clear cell acanthoma were almost identical to those of normal epidermis, although some antibodies gave a different staining pattern between clear cell acanthoma and normal epidermis. The expression of cytokeratins in psoriatic epidermis has been reported to change as a result of abnormal differentiation or maturation. Clear cell acanthoma showed a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus and discoid lupus erythematosus. We speculate that clear cell acanthoma is a localized form of inflammatory dermatosis rather than a neoplasm.

References

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Citations

Mar 24, 2000·The British Journal of Dermatology·T Ohnishi, S Watanabe
Aug 2, 2007·The American Journal of Dermatopathology·Daniel C ZedekWain L White
Apr 20, 2012·The American Journal of Dermatopathology·Asok Biswas, Meera Mahalingam
Apr 29, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marco ArdigoMelissa Gill
Sep 29, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ching-Chi ChiHuei-Sheng Huang
Jun 10, 2004·The Journal of Dermatology·Hiroshi KawaguchiMizue Takeuchi
May 30, 2009·Journal of Cutaneous Pathology·Christine J Ko, Antonio Subtil
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·Leonardo BugattiCarlo Tomasini
Sep 21, 2006·Experimental Dermatology·Daniela KovacsMauro Picardo
Oct 12, 2010·International Journal of Dermatology·L Katie MorrisonH Nicholas Shamma
Nov 23, 2012·Clinical and Experimental Dermatology·T Tempark, T Shwayder
Oct 15, 2013·Journal of Cutaneous Pathology·Sara C ShalinThomas D Horn
Nov 14, 1997·The Journal of Dermatology·K YamasakiT Manabe
Mar 30, 2013·Anais Brasileiros De Dermatologia·Rossana Ruth Garcia da VeigaMario Fernando Ribeiro de Miranda
Jul 11, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·H S InalözA G Knight
Dec 6, 2005·Plastic and Reconstructive Surgery·Shu-Hui Wang, Ching-Chi Chi
Jul 20, 2019·Journal of Cutaneous Pathology·Michael Z Wang, Richard C Jordan
Apr 7, 2015·Advances in Anatomic Pathology·Nancy ChengDavid S Cassarino
Jun 24, 2019·Head and Neck Pathology·Prokopios P ArgyrisIoannis G Koutlas
Sep 30, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar WagnerMichael Max Sachse
Sep 21, 2020·Dermatologic Therapy·Algün Polat EkinciNesimi Büyükbabani
Aug 24, 2021·The Journal of Investigative Dermatology·Aubriana McEvoyMartha Laurin Council

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