Immunohistochemical characterization of putative primary afferent (sensory) myenteric neurons in human small intestine

Autonomic Neuroscience : Basic & Clinical
Axel BrehmerW Neuhuber

Abstract

Pseudouni- or multiaxonal Dogiel type II neurons are the intrinsic primary afferent (sensory) neurons (IPANs) in the guinea pig small intestine. Our aim was to decipher the chemical code of human myenteric type II neurons and to establish their putative vertical projections, i.e., from the myenteric plexus to the submucosa/mucosa. Additionally, we tried to distinguish them chemically from uniaxonal, dendritic type V neurons displaying, at first glance, similar shapes, i.e., smoothly contoured cell bodies with several long processes. Wholemount preparations of the myenteric plexus were immunohistochemically double or triple stained for neurofilaments (NF) and one or two of the following peptides: calbindin, calretinin (CR), calcitonin gene-related peptide (CGRP), somatostatin (SOM) and substance P (SP). In each triple stained wholemount three counts were conducted: (1) NF-positive pseudouni- or multiaxonal (type II) neurons including their reactivities for the above peptides, (2) uniaxonal or NF-negative neurons displaying coreactivities for the above peptides and (3) NF-reactive type V neurons taking into account their reactivities for the above markers. Additionally, type II neurons, which had an axon leading into (disrupted) ...Continue Reading

References

Jan 1, 1992·Acta Anatomica·J P TimmermansM H De Groodt-Lasseel
Mar 14, 1998·Trends in Neurosciences·M Marín-Padilla
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S A SchnellM W Wessendorf
Mar 10, 2001·The Journal of Comparative Neurology·W CornelissenJ P Timmermans
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Camilleri
Oct 3, 2002·The Journal of Comparative Neurology·Axel BrehmerWinfried Neuhuber
Dec 4, 2003·The Journal of Comparative Neurology·Kulmira NurgaliJohn B Furness

❮ Previous
Next ❯

Citations

Mar 19, 2005·Histochemistry and Cell Biology·A BrehmerH Rupprecht
May 31, 2006·Histochemistry and Cell Biology·John B FurnessDaniel P Poole
Sep 21, 2007·Histochemistry and Cell Biology·Simone WeidmannAxel Brehmer
Sep 23, 2008·Histochemistry and Cell Biology·Tobias M LindigAxel Brehmer
Sep 8, 2012·Histochemistry and Cell Biology·Cornelia Irene HaglKarl-Herbert Schäfer
Aug 28, 2009·Cell and Tissue Research·Martin BeckAxel Brehmer
Jan 16, 2010·Journal of Gastroenterology and Hepatology·Oliver Grundmann, Saunjoo L Yoon
Oct 31, 2013·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raj P Kapur
Nov 10, 2013·Histochemistry and Cell Biology·Nicholas BeuscherAxel Brehmer
Jul 26, 2014·Histochemistry and Cell Biology·Samir JabariAlexandre B M da Silveira
Jun 23, 2009·Journal of Cellular and Molecular Medicine·Marlene M Hao, Heather M Young
Jan 25, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M A MurphyD A Wattchow
Jul 29, 2008·Journal of Anatomy·Juliane MünnichHelga Pfannkuche
Jan 5, 2008·Journal of Anatomy·M B LevantiJ A Vega
Feb 12, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M HarringtonB R Southwell
Mar 23, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P P K M GamageM J Saffrey
Aug 12, 2006·Vascular Pharmacology·Gareth J SangerJohn B Furness
Apr 18, 2006·Autonomic Neuroscience : Basic & Clinical·Alessandro LecciCarlo Alberto Maggi
Jan 11, 2018·International Journal of Molecular Sciences·Katharina ZetzmannAxel Brehmer
May 21, 2009·The American Journal of Gastroenterology·Elena F VerduJoseph A Murray
Mar 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andreas KustermannAxel Brehmer
Feb 16, 2005·Current Opinion in Gastroenterology·David Grundy, Michael Schemann
Mar 31, 2005·Journal of Clinical Gastroenterology·Michael D Gershon
Sep 1, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Matthias WolfAxel Brehmer
Dec 6, 2005·Histochemistry and Cell Biology·A BrehmerW Neuhuber
Mar 28, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raj P KapurMiriam R Conces
Dec 28, 2006·Cells, Tissues, Organs·Sonja KappAxel Brehmer
Feb 6, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Fiorella GiancolaRoberto De Giorgio
Jul 28, 2020·Toxins·Sławomir GonkowskiKrystyna Makowska
Sep 21, 2010·The Journal of Comparative Neurology·Leen UyttebroekLuc Van Nassauw
Sep 27, 2018·Histochemistry and Cell Biology·Winfried Neuhuber, Jürgen Wörl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved