PMID: 11317685Apr 25, 2001Paper

Immunohistochemical characterization of the perivascular infiltrate cells in tissues adjacent to stainless steel implants compared with titanium implants

Archives of Orthopaedic and Trauma Surgery
M ThewesJ Ring

Abstract

Metallic orthopaedics implants are composed of elements that are known to be skin sensitizers in the general population. In this study, we analyzed the cells of perivascular infiltration in the tissue adjacent to titanium (n = 23) and steel (n = 8) implants after explantation of the metals by immunohistochemical methods. The following panel of monoclonal antibodies were used as parameters: CD 1a (Langerhans cells), CD 4 (T-helper cells), CD 8 (T-suppressor cells), CD 11c (monocytes and macrophages), CD 45 RO (memory cells), CD 45 RA (naive cells), eosinophil cationic proteins (ECP), neutrophil elastase, and HLA-DR. The number of perivascular total cells did not differ significantly. All cells were identified in both metal subgroups, but a statistical difference was not seen in the above-mentioned parameters. We conclude that sensitization to metals is possible in the tissue adjacent to steel and titanium implants, because all cells which play an important role in allergic delayed-type hypersensitivity (type IV) reactions are present. This phenomenon may be called a 'pre-sensitization' phase, because no sensitization or allergic reactions were seen in our cases. Second, in the present study, a statistical difference was not seen...Continue Reading

Citations

Jan 23, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P ThomasUNKNOWN Gemeinsame Stellungnahme des Arbeitskreises Implantatallergie (AK 20) der Deutschen Gesellschaft für Orthopädie und Orthopäd
Feb 12, 2005·Der Orthopäde·A SchuhR Forst
Oct 20, 2009·Journal of Biomedical Materials Research. Part a·Dieter CadoschLuis Filgueira
Aug 18, 2009·Clinical Oral Implants Research·Ralf J KohalFrank Butz
Aug 19, 2008·Clinical Oral Implants Research·Alberto SiciliaAntonio Maestro
Jan 22, 2017·Der Unfallchirurg·Alexander JoerisDankward Höntzsch
Mar 1, 2009·Metallomics : Integrated Biometal Science·Erwin Ph ChanLuis Filgueira
Oct 8, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katrin Jost-Albrecht, Willy Hofstetter
Jan 13, 2015·Dermatitis : Contact, Atopic, Occupational, Drug·Megan M Wood, Erin M Warshaw
Feb 2, 2013·Dental Materials Journal·Hiroshi ItoMasao Yoshinari

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