PMID: 9539314Apr 16, 1998Paper

Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma

Journal of Korean Medical Science
H-S ParkH E Yim

Abstract

Toluene diisocyanate (TDI) is the most prevalent agent in occupational asthma (OA) in Korea. The immuno-pathologic mechanism for TDI-induced bronchoconstriction remains to be clarified. We studied the immunohistochemical finding of inflammatory cells in bronchial mucosa in subjects with TDI-induced asthma. Fiberoptic bronchial biopsy specimens were obtained from nine subjects with TDI-induced asthma. Six allergic asthma sensitive to house dust mite were enrolled as controls. Bronchial biopsy specimens were examined by immunohistology with a panel of monoclonal antibodies to mast cell tryptase (AA1), secretary form of eosinophil cationic protein (EG2), pan T-lymphocyte (CD3) and neutrophil elastase (NE). There was a significant increase in the number of AA1+, EG2+ and NE+ cells in TDI-induced asthma compared to those of allergic asthma (p=0.02, p=0.04, p=0.03, respectively). No significant differences were observed in the number of CD3+ cells (p=0.27). These findings support the view that neutrophil recruitment together with eosinophil and mast cell, may contribute to the bronchoconstriction induced by TDI.

Citations

Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·K S Jung, H S Park
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Nov 25, 2011·Respiratory Medicine·Kawa Amin
Nov 18, 2017·Experimental & Molecular Medicine·Duy L PhamHae-Sim Park
Aug 2, 2008·Immunopharmacology and Immunotoxicology·So Ri Kim, Yong Chul Lee
Jul 21, 2009·International Journal of Occupational Medicine and Environmental Health·Elzbieta PiskorskaTomasz Tyrakowski
Jan 3, 2019·Current Opinion in Allergy and Clinical Immunology·Youngwoo ChoiHae-Sim Park
Jan 18, 2013·Current Opinion in Allergy and Clinical Immunology·Yoo Seob ShinHae-Sim Park
May 14, 2020·Allergy, Asthma & Immunology Research·Youngwoo ChoiHae Sim Park
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ParkK Kang
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H-S ParkY-Y Kim

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