Immunohistochemical characterization of endocervical papillary serous carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Sharon Nofech-MozesMahmoud M Khalifa

Abstract

Endocervical adenocarcinomas are rare and aggressive neoplasms. Papillary serous endocervical adenocarcinomas are the rarest form of endocervical adenocarcinomas. This tumor exhibits morphologic similarities to its counterparts commonly seen in the endometrium, fallopian tubes, ovaries, and peritoneum, which are known to have an aggressive behavior. Because of the rarity of this tumor, little is known about its immunophenotyping. In this study, we included ten cases of papillary serous carcinomas arising from the uterine cervix (PSCC) diagnosed in the absence of a primary endometrial malignancy. We studied their immunohistochemical profile, using a panel of antibodies against Ki67, bcl-2, p53, carcinoembryonic antigen (CEA), and CD10, and compared them to 20 consecutive cases of cervical adenocarcinoma of conventional cell subtypes (CAC) (15 mucinous, 3 adenosquamous, and 2 endometrioid). Immunostaining was recorded semiquantitatively. Patients with PSCC ranged in age from 27 to 79 years (mean = 51.6 +/- 19.1), while the conventional cell subtypes control group were 28-90 years old (mean = 47.5 +/- 16.9). Only p53 and CEA immunostaining significantly correlated with the PSCC morphology (P= 0.001 and P= 0.016, respectively) as s...Continue Reading

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Citations

Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sharon Nofech-MozesZeina Ghorab
Apr 24, 2010·The American Journal of Surgical Pathology·W Glenn McCluggageKathryn Kennedy
Oct 8, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anais Malpica, Michael T Deavers
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Dec 29, 2013·Gynecologic Oncology Case Reports·Weiwei TangGuiping Wan
Feb 3, 2018·Gynecologic and Obstetric Investigation·Joanna Jonska-GmyrekBeata Kotowicz
Jun 24, 2017·Archives of Pathology & Laboratory Medicine·Edyta C Pirog
Jun 1, 2018·The American Journal of Surgical Pathology·Simona StolnicuRobert A Soslow
Jun 8, 2018·The American Journal of Surgical Pathology·Anjelica HodgsonCarlos Parra-Herran
Feb 4, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sharon Nofech-Mozes, Mahmoud A Khalifa
Jul 25, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sharon Nofech-MozesZeina Ghorab
Nov 6, 2014·Pathology Oncology Research : POR·Shinichi TogamiHitoshi Tsuda

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