Immunohistochemical classification of gastric cancer based on new molecular biomarkers: a potential predictor of survival

Virchows Archiv : an International Journal of Pathology
Cristina Díaz Del ArcoMª Jesús Fernández Aceñero

Abstract

Several classification systems have been described for stratifying patients with gastric carcinoma (GC). However, their prognostic value is low, and there is an urgent need for identification of molecular markers and development of new classifications. Retrospective study of 206 cases of GC diagnosed and surgically resected in our hospital between 2000 and 2017. Clinicopathological features of all cases were assessed and tissue microarrays were constructed for immunohistochemical (IHC) study. Patients were stratified based on IHC results. Mean patient age was 71 years and most patients were male (54.6%). Most tumors were located in the gastric antrum and body, and they were mostly fungoid or ulcerative lesions. GC were mainly intestinal-type tumors and 60.3% were diagnosed at pT3. 56.2% of patients showed recurrences and 29.4% died due to GC. According to our IHC classification, 23.5% of tumors showed microsatellite instability, 6% were E-cadherin negative, 53.5% were stable-p53 not overexpressed, and 17% were stable with p53 overexpression. IHC classification was significantly correlated with patient gender, gross morphology, Laurén classification, tumor necrosis, perineural infiltration, type of leading edge, and patient outc...Continue Reading

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Citations

Feb 19, 2019·Journal of Cellular Biochemistry·Sifeng HuFanmei Meng
Jun 11, 2020·The American Journal of Surgical Pathology·Yuta TsugenoHiroshi Kawachi
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Mar 18, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Cristina Díaz Del ArcoMa Jesús Fernández Aceñero

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