Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa

Stomatologii︠a︡
A A IvinaI I Babichenko

Abstract

The paper presents an example of differential diagnostic studies for pyogenic granuloma and oral squamous cell carcinoma (SCC). In the described case immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional histological procedure proved to be inconvenient for adequate diagnostics. The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms.

References

Mar 3, 2012·G3 : Genes - Genomes - Genetics·Christopher HeffelfingerAllen E Bale
Dec 10, 2015·Seminars in Cutaneous Medicine and Surgery·Amanda SiuDaniel M Ramos
Apr 5, 2016·Journal of Indian Society of Periodontology·Abbayya KeshavaRufi Patel

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