PMID: 1856347Apr 1, 1991

Immunohistochemical demonstration of actinically damaged elastic fibers in keratoacanthomas: an aid in diagnosis

Journal of Cutaneous Pathology
R C JordanJ Jambrosic

Abstract

The inclusion of elastic fibers within the epithelium of keratoacanthomas is a phenomenon suggested to be an aid in differentiating this lesion from squamous cell carcinoma. Antilysozyme antibodies have recently been noted to stain actinically damaged elastic fibers but not those from sunprotected skin. In this study, 54 keratoacanthomas and 46 squamous cell carcinomas were stained with a histochemical elastic tissue stain and polyclonal antibody to lysozyme using an immunoperoxidase technique. Elastic fibers were demonstrated in keratoacanthomas (37/54, 68%) significantly more often than squamous cell carcinomas (12/46, 26%) (p less than 0.001) using both techniques. This study confirms that the inclusion of elastic fibers occurs significantly more often in keratoacanthomas than squamous cell carcinomas. These elastic fibers were also actinically damaged, suggesting a role for sun damage in the evolution of keratoacanthoma.

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Dec 1, 1977·Journal of Cutaneous Pathology·I P JaneckaB Cosman
Mar 1, 1975·The Journal of Dermatologic Surgery·M D ChaletA Bernard Ackerman
Feb 1, 1986·Journal of the American Academy of Dermatology·B R SmollerS Banks-Schlegel
Apr 1, 1988·The British Journal of Dermatology·T J Stephenson, D W Cotton
Mar 8, 1969·Lancet·I T Jackson
Apr 1, 1984·Journal of the American Academy of Dermatology·J W Patterson
Jun 1, 1984·Archives of Dermatology·J Kingman, J P Callen
Oct 1, 1980·Journal of Cutaneous Pathology·W H Kern, M K McCray

Citations

Jan 1, 1995·Journal of the American Academy of Dermatology·R M LavkerK H Kaidbey
Dec 12, 2012·Journal of Cutaneous Pathology·Viktoryia KazlouskayaChristian Andres
Jul 21, 2004·Pathology International·Amiko OhashiYuh Fukuda
Oct 1, 1993·Journal of Cutaneous Pathology·P Phillips, K F Helm
Jul 20, 2006·Issues in Mental Health Nursing·Barbara L Zust
Jun 3, 2020·Qualitative Health Research·Emily C Wacker, Megan L Dolbin-MacNab
Oct 20, 2012·Journal of Family Theory & Review·David C BellAron E Dibacco
Jun 1, 1997·Acta Ophthalmologica Scandinavica·S A SchelliniC E Bacchi
Jul 17, 2008·Journal of Cutaneous Medicine and Surgery·Renata Ferreira MagalhãesAparecida Machado de Moraes
Nov 29, 2013·International Journal of Surgical Pathology·Phyu P AungMeera Mahalingam

Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Peroxidase-Antiperoxidase Complex Technique
Keratoacanthoma
Malignant Neoplasm of Skin

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2021 Meta ULC. All rights reserved