PMID: 376064May 11, 1979Paper

Immunohistochemical demonstration of catechol-o-methyltransferase in mammalian brain

Brain Research
G P KaplanC R Creveling

Abstract

Catechol-O-methyltransferase (COMT)(EC 2.1.1.6) was localized using fluorescence immunohistochemistry in rat liver and kidney and in rat, chinchilla, and bovine brains. In the brain, specific fluorescence was visable only in non-neuronal cellular elements in all three species. Ventricular ependymal cells and cells of the choroid plexuses exhibited the greatest intensity of immunofluorescence. Glial immunofluorescence appeared prominently in large myelinated fiber tracts. Interfascicular and perineuronal satellite oligodendrocytes as well as fibrous astrocytes were immunoreactive, though myelin itself did not exhibit a positive reaction. Bergmann glial cells in the cerebellum also stained brightly for COMT. Although this study indicates that the predominant localization of COMT is non-neuronal, it is important to note that the presence of small quantities of this enzyme in neurons cannot be excluded. The patterns of localization observed in the non-neuronal elements suggest that this enzyme may function as a barrier to free diffusion of catechol compounds within the central nervous system.

References

Feb 1, 1975·The Biochemical Journal·H L White, J C Wu
Apr 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B K Hartman
Jun 1, 1969·Life Sciences·R I KatzI J Kopin
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Oct 1, 1972·British Journal of Pharmacology·G BurnstockM E Wright
Jan 1, 1968·Physiological Reviews·R P Bunge
Aug 25, 1971·European Journal of Biochemistry·P BallH Breuer
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
Jan 1, 1971·Journal of Neurochemistry·B Jarrott
Aug 1, 1969·Biochemical Pharmacology·M Assicot, C Bohuon
Oct 1, 1965·Life Sciences·M AlbericiE De Robertis

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Citations

Jun 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·A ZumsteinK Starke
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM Yahr
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM D Yahr
Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·A DingS Hoyer
May 4, 1984·European Journal of Pharmacology·G S SarnaG Curzon
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·W T ChanceJ E Fischer
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·C OkudaR Kuczenski
Aug 16, 1995·Biochimica Et Biophysica Acta·K LundströmI Ulmanen
Jan 1, 1985·Neurochemistry International·B H Westerink
Jan 1, 1986·Neurochemistry International·W E HeydornD M Jacobowitz
Jul 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D J HealW R Buckett
Jan 1, 1979·Progress in Neurobiology·K E Moore, S M Wuerthele
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Jul 1, 1996·Neuroscience·T KarhunenP Panula
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T KarhunenP Panula
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P LevittX O Breakefield
Nov 4, 2000·Neuroreport·G YadidD S Goldstein

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