PMID: 9182245Feb 1, 1996Paper

Immunohistochemical demonstration of GABAB receptors in the rat gastrointestinal tract

Neurochemical Research
K NakajimaH Kimura

Abstract

Immunohistochemical localization of GABA(B)-receptors was demonstrated in the rat gastrointestinal tract using a monoclonal antibody (GB-1) raised against the purified GABA(B)-receptor. Immunoreactive staining for GABA(B)-receptors was found in some populations of endocrine, muscular and neuronal components in the stomach and gut wall. Positive mucosal epithelial, probably endocrine, cells were distributed throughout the stomach and intestine. Double immunostaining indicated that such positive cells for GABA(B)-receptors often co-possessed serotonin in the small intestine but not in the gastric body. In the muscular layer of the digestive canal, positive staining was seen as dotty granules punctuated on the surface of muscle fibers. In the enteric nervous system, positive neuronal somata were found in both submucosal and myenteric ganglia throughout the entire canal extending from the stomach to the rectum. This is the first report to visualize the cellular localization of GABA(B)-receptors in the gastrointestinal system of the rat, and should provide a fundamental basis for future studies on gastrointestinal functions regulated by GABA(B)-receptors.

References

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Citations

Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sam X Cheng
Jun 2, 2009·Brain, Behavior, and Immunity·Paul ForsytheJohn Bienenstock
Jun 24, 2004·British Journal of Pharmacology·Laura Piqueras, Vicente Martinez
Jul 16, 2009·Genesis : the Journal of Genetics and Development·Emilio CasanovaBernhard Bettler
Jul 7, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mark Lyte
Apr 18, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mikhail SkoblovAncha Baranova
Dec 16, 2010·Parasite Immunology·S Z HasnainR K Grencis
Dec 21, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michelangelo AuteriRosa Serio
Jan 29, 2000·Microscopy Research and Technique·E KurodaM Shimada
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Anthony Krantis
Dec 15, 2016·Frontiers in Microbiology·Roberto Mazzoli, Enrica Pessione
Mar 19, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M KurjakB Otto
Jun 3, 2021·International Journal of Molecular Sciences·Marina Romaní-PérezYolanda Sanz

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