PMID: 8789398Dec 1, 1995Paper

Immunohistochemical demonstration of human carbonic anhydrase isoenzyme II in brain tumours

The Histochemical Journal
Anna-Kaisa ParkkilaH Rajaniemi

Abstract

Carbonic anhydrase (CA) is a functionally important enzyme in the central nervous system (CNS), where it is involved in the control of the acid-base balance and regulates the production of cerebrospinal fluid (CSF). Isoenzyme II (CA II) is the most widely distributed CA in the CNS, being present in at least myelin, oligodendrocytes, astrocytes and the choroid plexus. This study was undertaken to examine the presence of CA II in different brain tumours from 31 patients. Specific antibodies recognizing CA II were used in immunoperoxidase staining of tumour specimens. Anti-CA I and VI sera and normal rabbit serum were used as controls. CA II-positive staining was observed in all the astrocytic tumours (n = 9), oligodendrogliomas (n = 3) and medulloblastomas (n = 3). The most malignant tumours exhibited the strongest staining. In addition, four acoustic neurinomas, one plexiform neurofibroma, one choroid plexus papilloma, one ependymoblastoma and one subependymoma expressed the enzyme. Meningiomas (n = 4) and neuronal tumours (n = 4), including one dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos), were negative. Anti-CA I, VI and normal rabbit sera showed no specific staining in tumour cells. The presence of CA II in t...Continue Reading

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Citations

Nov 21, 1998·Clinical Neurology and Neurosurgery·R M GaudioM L Rossi
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ParkkilaW S Sly
Jan 19, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seppo ParkkilaMarkku Miettinen
Apr 30, 2011·World Journal of Gastrointestinal Oncology·Giulia MalaguarneraClorinda Mazzarino
Sep 22, 2010·Journal of Cellular Physiology·Scott K ParksJacques Pouyssegur
May 28, 2017·Pathophysiology : the Official Journal of the International Society for Pathophysiology·David E ConnorJ Steven Alexander
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J SaarnioW S Sly
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Oct 9, 2007·Journal of Neurosurgery·Zachary A SmithJorge A Lazareff
Sep 15, 2005·The American Journal of Surgical Pathology·Laszlo HegyiFederico Roncaroli
Jul 3, 2020·Cancers·Joonas HaapasaloSeppo Parkkila

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