Immunohistochemical demonstration of lysozyme in pseudopyloric glands in chronic cholecystitis

Virchows Archiv. A, Pathological Anatomy and Histopathology
J J van den OordV J Desmet

Abstract

Gallbladders of 12 cases with chronic cholecystitis showing pseudopyloric glands (PPG) and of 18 cases with acute cholecystitis or chronic cholecystitis but without PPG were examined by the peroxidase - antiperoxidase (PAP) method using rabbit antibody against human lysozyme (LM). LM-immunoreactivity was detected in the cytoplasm of PPG and, to a lesser extent, in the pits of epithelial crypts that gave rise to PPG. No LM was found in normal gallbladders; in cases of cholecystitis without PPG, LM-immunoreactivity was restricted to infiltrating inflammatory cells. The presence of LM in PPG suggests that PPG represent functional metaplastic areas, involved in the non-specific defence mechanisms through participation of LM.

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Citations

Jan 1, 1987·Histochemistry·G Karayannopoulou, I Damjanov
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·K AroniN X Papacharalampous
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M YamamotoE Tahara
Mar 1, 1989·Pathology, Research and Practice·M YamamotoE Tahara
Apr 2, 2013·Digestive Diseases and Sciences·Shuchi AgarwalFrancis A Farraye
Jan 1, 1987·Acta Pathologica Japonica·M TatematsuN Ito

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