Immunohistochemical demonstration of TGF-beta-receptor type II in human pituitary adenomas

Acta histochemica
K FujiwaraT Yoshimoto

Abstract

To investigate whether the signalling pathway of transforming growth factor-beta (TGF-beta) is active in human pituitary tumors, an antibody against TGF-beta-receptor type II (TGF beta-R-II) was prepared to demonstrate immunohistochemically TGF beta-R-II expression in 48 cases of human pituitary adenoma. Positive immunoreactivity for TGF beta-R-II was found in 26 adenomas: 1 of 2 somatotroph cell adenomas, 1 of 9 mammotroph cell adenomas, 0 of 3 mixed somatotroph and mammotroph cell adenomas, 5 of 9 corticotroph cell adenomas, 3 of 3 gonadotroph cell adenomas, 12 of 15 plurihormonal adenomas, and 4 of 7 null cell adenomas. Expression of TGF beta-R-II varied between histological types of adenomas and increased with decreasing grades of differentiation. It is concluded that TGF-beta-mediated signals may be passed via TGF beta-R-II in pituitary tumors.

References

Sep 15, 1989·International Journal of Cancer. Journal International Du Cancer·K YoshidaE Tahara
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T MasuiC C Harris
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W E RussellH L Moses
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L BraunN Fausto
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H J Ristow
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M E KadinD George

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