Abstract
To investigate whether the signalling pathway of transforming growth factor-beta (TGF-beta) is active in human pituitary tumors, an antibody against TGF-beta-receptor type II (TGF beta-R-II) was prepared to demonstrate immunohistochemically TGF beta-R-II expression in 48 cases of human pituitary adenoma. Positive immunoreactivity for TGF beta-R-II was found in 26 adenomas: 1 of 2 somatotroph cell adenomas, 1 of 9 mammotroph cell adenomas, 0 of 3 mixed somatotroph and mammotroph cell adenomas, 5 of 9 corticotroph cell adenomas, 3 of 3 gonadotroph cell adenomas, 12 of 15 plurihormonal adenomas, and 4 of 7 null cell adenomas. Expression of TGF beta-R-II varied between histological types of adenomas and increased with decreasing grades of differentiation. It is concluded that TGF-beta-mediated signals may be passed via TGF beta-R-II in pituitary tumors.
References
Feb 21, 1992·Cell·H Y LinH F Lodish
Dec 11, 1992·Cell·J L WranaJ Massagué
Jan 1, 1992·Acta Neuropathologica·H Ikeda, T Yoshimoto
Apr 1, 1990·Experimental Cell Research·H IchijoK Miyazono
Feb 1, 1989·Journal of Cellular Biochemistry·J R KellerF W Ruscetti
Sep 15, 1989·International Journal of Cancer. Journal International Du Cancer·K YoshidaE Tahara
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T MasuiC C Harris
Feb 13, 1987·Cell·C KnabbeR B Dickson
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W E RussellH L Moses
Aug 1, 1987·Endocrinology·M K SkinnerH L Moses
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L BraunN Fausto
Jul 17, 1987·Science·G B Silberstein, C W Daniel
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H J Ristow
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M E KadinD George
Nov 19, 1993·Cell·P FranzénK Miyazono
Nov 1, 1993·The Journal of Pathology·P SchmidW Seiler
May 28, 1993·Science·R H ChenR Derynck
Citations
Jun 18, 2002·Neurologia Medico-chirurgica·Hirofumi NaganumaHideaki Nukui
Dec 25, 2015·The Journal of Endocrinology·M Victoria RecouvreuxGraciela Díaz-Torga
Oct 21, 2000·Endocrine Reviews·J Schwartz
Jul 28, 2007·Endocrinology·Paul G FarnworthJock K Findlay
Jun 8, 2018·Endocrine-related Cancer·Juan Pablo PetitiAlicia Inés Torres
Oct 16, 2019·Nature Communications·Richard H KimuraSanjiv S Gambhir
Dec 14, 1999·The American Journal of Pathology·H OkaR V Lloyd