PMID: 9524317Apr 3, 1998Paper

Immunohistochemical demonstration of the plasminogen activator system in human gingival tissues and gingival fibroblasts

Journal of Periodontal Research
Y XiaoP M Bartold

Abstract

The relative distribution of urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) was studied in cultured human gingival fibroblasts, healthy gingival tissues and inflamed gingival tissues by immunohistochemistry. In cultured gingival fibroblasts t-PA, u-PA and PAI-1 were expressed in cytoplasm; u-PA and PAI-1 were more intensely stained than t-PA; PAI-2 was not detectable in gingival fibroblasts. Following interleukin 1 beta (IL-1 beta) stimulation, the intensity of intracellular staining for t-PA was increased and a number of cells staining strongly for PAI-2 were seen; no difference in the intensity of immunostaining level was noted for the expression of u-PA and PAI-1 between IL-1 beta stimulated cells and unstimulated cells. In healthy gingival tissues, u-PA and PAI-1 displayed a wide distribution throughout all the connective tissue and epithelium; t-PA localized mainly in the connective tissue while PAI-2 showed little association with the connective tissue but did faintly stain in the epithelial layer. In inflamed gingival tissues, staining for t-PA was significantly increased in the extracellular ma...Continue Reading

References

Jul 1, 1991·International Journal of Radiation Biology·V W van HinsberghP Koolwijk
Oct 1, 1991·The Journal of Clinical Investigation·J D VassalliD Belin
Feb 1, 1991·Journal of Clinical Pathology·A J SimpsonB Bennett
Jan 1, 1991·Archives of Oral Biology·J SchmidD A Chambers
Jan 2, 1990·Molecular and Cellular Endocrinology·P A AndreasenS N Stacey
Feb 1, 1987·The Journal of Experimental Medicine·A WohlwendJ D Vassalli
Jan 1, 1988·Enzyme·E K Kruithof
Mar 1, 1987·Archives of Biochemistry and Biophysics·P M Bartold, R C Page
Jul 1, 1995·Histopathology·S A WhawellJ N Thompson
Sep 1, 1993·The International Journal of Biochemistry·T OikawaH Izumi
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Sep 1, 1995·Archives of Oral Biology·J M BrownD A Chambers

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Citations

Jan 29, 2008·Journal of Periodontal Research·A A DeCarloB Glenn
Jul 15, 2015·Molecular Oral Microbiology·J-Y LeeB-K Choi
Apr 4, 2002·Biological Chemistry·Bertil Kinnby
Nov 24, 2020·Periodontology 2000·Luciana Macchion ShaddoxLuigi Nibali
Jun 19, 2019·Journal of Oral Biology and Craniofacial Research·Puja DebnathSrikanta Kumar Rath

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