Immunohistochemical detection of autotaxin (ATX)/lysophospholipase D (lysoPLD) in submucosal invasive colorectal cancer.

Journal of Gastrointestinal Cancer
Shinsuke KazamaHirokazu Nagawa

Abstract

Autotaxin (ATX) is molecularly identical to lysophospholipase D (lysoPLD) and is a main enzyme producing lysophosphatidic acid (LPA), which mediates a broad range of cellular responses including stimulation of cell motility. Using immunohistochemical staining, we examined the expression of ATX/lysoPLD in 98 cases of early colorectal cancer with submucosal invasion. ATX/lysoPLD was highly expressed in infiltrating cells in tumor tissue in the submucosal layer, which were characterized as mast cells. The number of ATX/lysoPLD-positive cells was significantly greater in tumors with a macroscopically depressed lesion than in tumors without depression. The density of ATX/lysoPLD-positive cells tended to have a positive correlation with microvessel vascular density (MVD), while it was not correlated with vessel invasion and nodal metastases as well as lymphovascular vessel density (LVD). Our results suggest that local production of LPA through ATX/lysoPLD may weakly correlate with formation of a depressive lesion and tumor angiogenesis in the early stage of colorectal cancer.

Associated Clinical Trials

Mar 31, 2020·Mary Gamal Sudky

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Citations

Nov 20, 2012·The Journal of Surgical Research·Nicholas J SkillMary A Maluccio
Nov 30, 2014·Experimental Cell Research·C Chris Yun, Ajay Kumar
Mar 20, 2014·Journal of Lipid Research·Yun C YungJerold Chun
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming QuanQian Huang
Mar 29, 2019·Medicine·Yingbo ShaoHui Liu
May 21, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chieko KitamuraSoichiro Ishihara

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