PMID: 46755Jan 1, 1975

Immunohistochemical detection of changes in growth hormone cells in rat pituitaries in protein deficiency

The British Journal of Nutrition
T Drummond


1. An immunohistochemical method was used to study the effect of a low-protein diet on growth hormone (GH) cells in the pituitaries of developing rats. The deficient diet (80 g protein/kg) was administered during gestation and lactation, or during the time after weaning until 90 d of age, or during both periods. 2. GH-cell changes were much more striking in males than in females. 3. In males, GH-producing cells were usually reduced in size and number in all treatments. The effect was most intense when protein deprivation occurred throughout gestation and sucking, and continued until 90 d of age, but it was also evident in animals given the low-protein diet only after weaning. Recuperation appeared to be almost complete when offspring of deprived dams were fed on a normal diet after weaning. 4. It is concluded that a low-protein diet reduces the amount of GH in the rat pituitary in a way similar to that with a protein-free diet.


Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·L C AlvarezW P VanderLaan
Apr 1, 1970·Archives of Disease in Childhood·R D Milner
Oct 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A Trenkle
Sep 1, 1971·The British Journal of Nutrition·F BeasS Arenas
May 1, 1968·The American Journal of Clinical Nutrition·B L PimstoneP Murray
Apr 17, 1969·Histochemie. Histochemistry. Histochimie·B Ehinger, B Falck
May 1, 1967·The Journal of Cell Biology·P K Nakane, G B Pierce
May 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·E B SCOTT
Aug 1, 1957·Archives of Disease in Childhood·C TEJADA, A B RUSSFIELD
May 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·H H SREBNIKM E SIMPSON
May 1, 1962·Endocrinology·H H SREBNIK, M M NELSON
Jan 1, 1964·The Journal of Nutrition·B F Chow, C J Lee
Apr 1, 1965·Endocrinology·R C FRIEDMANN, S REICHLIN

Related Concepts

Lactation, Prolonged
Protein Deficiency
Staining and Labeling
Recombinant Growth Hormone
Pituitary Stalk

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