PMID: 9421074Jan 8, 1998Paper

Immunohistochemical detection of cyclin A with reference to p53 expression in endometrial endometrioid carcinomas

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
T ShiozawaS Fujii

Abstract

Cyclins are essential proteins in cell cycle control, and their deranged expression has been reported to be associated with malignant transformation. Involvement of cyclins in the development of endometrioid carcinomas of the endometrium was studied immunohistochemically using antibodies against both cyclin A and tumor suppressor gene product p53, and their expression was compared with that of Ki-67 antigen. Sixty-two cases of endometrial endometrioid carcinoma and 20 cases of normal endometrium (10 proliferative and 10 secretory phase) were examined. Of the 62 endometrioid carcinomas, atrophic endometrium and hyperplasia were found adjacent to the cancers in 30 and 19 cases respectively. Cyclin A was expressed in < 1% of the glandular cells of normal endometrium in the proliferative phase and in hyperplasia, but was negligible in normal secretory phase and atrophic endometrium. p53 was almost always negative in normal endometrium and hyperplasia. Of the 62 endometrioid carcinomas, 12 tumors (19.4%) overexpressed cyclin A and 21 tumors (33.8%) overexpressed p53 (positive cells > 1%). Cyclin A and p53 were more frequently expressed in poorly differentiated tumors than in well differentiated tumors (cyclin A, p = 0.002; p53, p = ...Continue Reading

Citations

Sep 22, 1999·Pathology Oncology Research : POR·R Chetty, S Simelane
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayaselcukB Demirhan
Jul 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yasuhiro ItoNariaki Matsuura
Jun 1, 2000·Gynecologic Oncology·M J SchmitzM J Birrer
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·Y L ZhaiS Fujii
Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hiromichi NakabayashiMitsuhiro Hara
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Aug 17, 2000·The Journal of Veterinary Medical Science·Y MurakamiR Yamaguchi

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