Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours

The Journal of Laryngology and Otology
D AndreadisC Barbatis

Abstract

To investigate the topography of E-cadherin and its possible correlation with the histological phenotype of salivary gland tumours. Archival formalin-fixed, paraffin-embedded sections of 54 benign and 56 malignant tumours and 24 samples of normal and inflamed salivary gland tissue were studied immunohistochemically using an Envision/horseraddish peroxidase (HRP) technique. In normal and inflamed salivary gland samples, E-cadherin was expressed at the membrane of acinar, myoepithelial and ductal cells located at cell-cell contact points. Reduction and/or absence of E-cadherin was only observed in pleomorphic adenoma at the peripheral cells of the duct-like or island structures, or in the cells exhibiting plasmacytoid or stromal differentiation. Neoplastic epithelium in Warthin's tumours and in myoepithelial and oncocytic adenomas was strongly positive. Furthermore, a weak to moderate loss of expression which was related to tissue tumour subtype was seen in malignant tumours such as: adenoid cystic carcinomas; polymorphous low-grade adenocarcinomas; acinic cell carcinomas; and mucoepidermoid low-grade, epithelial-myoepithelial, lymphoepithelial and squamous low-grade carcinomas. Moderate to extreme loss or alternative cytoplasmic...Continue Reading

Citations

Feb 23, 2013·Clinical Oral Investigations·Marianthi KyrodimouIoannis S Vizirianakis
Mar 26, 2011·Pathology Research International·Timothy V WadeZubair W Baloch
Feb 9, 2010·Oral Oncology·Jia-Yo WuWei-Chung Vivian Yang
Apr 30, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kihoon NamOlga J Baker
Apr 18, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katarina ObtulovicovaJana Dvorackova
Sep 7, 2016·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Manfred HintermairMarkus Lang
Jun 29, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·N KehagiasK Antoniades
Oct 8, 2015·Head and Neck Pathology·Brennan A TesdahlRobert A Robinson

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