PMID: 9420872Jul 1, 1995Paper

Immunohistochemical detection of epidermal growth factor receptor lacks prognostic significance for breast carcinoma

Journal of the Society for Gynecologic Investigation
U J GöhringJ A Holt

Abstract

We sought to determine whether the immunohistochemical detection of epidermal growth factor receptor (EGF-R) in primary cancer tissues is of prognostic significance in patients with breast carcinoma. Paraffin-embedded tissues from 244 study subjects with primary breast carcinomas were tested immunohistochemically for the presence of EGF-R and were compared in a retrospective study with clinical outcome. Epidermal growth factor receptor was detected in the tumors of 49 (20.1%) of the 244 study subjects. The incidence of EGF-R detection was comparable in subjects with disease-free lymph nodes (T1-4, N0, M0, n = 111; EGF-R present 22.5%) or those whose nodes contained carcinoma (T1-4, N+, M0, n = 133; EGF-R present 18.9%). No reliable correlation was found in either group between EGF-R detection and clinical, functional, or morphologic prognostic indicators that included age, menopausal status, tumor size, tumor grade, nodal status, and hormone receptor status. Relapse-free survival and overall survival (median observation time 62.5 months) did not differ between patients with EGF-R-positive or EGF-R-negative breast carcinoma specimens. In our experience, the immunohistochemical determination of EGF-R in routine formalin-fixed, pa...Continue Reading

Citations

Jun 5, 2008·Breast Cancer Research : BCR·Christina MagkouIoanna Giannopoulou
Jun 24, 2008·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Li TalleyA R Frost

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