PMID: 6402707Feb 17, 1983Paper

Immunohistochemical detection of growth hormone-releasing factor in brain

Nature
B BlochR Guillemin

Abstract

The concept of a hypothalamic neurohumoral control for anterior pituitary secretion postulates the existence of a growth hormone-releasing factor (GRF) of neuronal origin that stimulates the pituitary gland to release growth hormone (GH). Such a compound has not yet been isolated and characterized from the brain, although there is extensive physiological and biochemical evidence for its existence (reviewed in ref. 2). However, a 44-amino-acid amidated peptide having the physiological properties of GRF as well as chemical similarities was recently isolated from a human pancreatic tumour that had caused acromegaly. Two shorter biologically active fragments of 40 and 37 residues were also isolated. The synthetic replicates of these human pancreas GRF (hpGRF) peptides specifically stimulate GH release in vitro and in vivo. Assuming similarity or identity between the putative hypothalamic GRF and the tumour-derived hpGRF, we have used immunohistochemistry to search for hpGRF-like immunoreactivity in the brain. We report here that antisera against the hpGRF1-40 peptide specifically stain neuronal cell bodies in the arcuate nucleus of the primate hypothalamus, with fibres projecting to the median eminence and ending in contact with po...Continue Reading

References

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Citations

Jan 1, 1985·Acta neurochirurgica·M O ThornerJ L Thominet
Oct 1, 2009·Irish Journal of Medical Science·R K CrowleyA Agha
Aug 12, 1983·Biochemical and Biophysical Research Communications·P BöhlenR Guillemin
Aug 5, 1985·Brain Research·T ImakiN Ling
Dec 10, 1986·Brain Research·S DaikokuI Nagatsu
Feb 1, 1995·Brain Research. Brain Research Reviews·T A LantosM Palkovits
Oct 1, 1987·Psychiatry Research·W H BerrettiniS Simmons-Alling
Sep 1, 1988·Psychiatry Research·W H BerrettiniL R Goldin
Aug 17, 1987·Regulatory Peptides·F J Vaccarino, K E Buckenham
Jul 1, 1983·Peptides·D M JacobowitzD L Loriaux
Sep 1, 1983·Molecular and Cellular Endocrinology·W SchlegelG R Zahnd
Jul 20, 2002·Frontiers in Neuroendocrinology·Eleni A Markakis
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·U GublerL P Gage
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K E MayoR M Evans
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J K McDonaldS M McCann

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