PMID: 16505585Mar 1, 2006Paper

Immunohistochemical detection of neurotrophin-3 and -4, and their receptors in mouse taste bud cells

Archives of Histology and Cytology
Masako TakedaHiroaki Tsunekawa

Abstract

Neurotrophin-3 (NT3) and neurotrophin-4 (NT4) affect the survival and maintenance of central and peripheral neurons. Using an immunohistochemical method, we examined whether the taste bud cells in the circumvallate papillae of normal mice expressed NT3, NT4, and their respective receptors TrkC and TrkB, and if so, what type of cells in the taste buds expressed them. Double immunostaining for either of them and PGP 9.5, NCAM, or gustducin was used to determine which cell types expressed which neurotrophins and receptors. Normal taste bud cells expressed NT3, NT4, and the TrkB receptor, but not TrkC. The percentage of NT3-immunoreactive cells among all taste bud cells was 89.0%, that of NT4-immunoreactive cells, 58.6%, and that of TrkB-immunoreactive cells, 80.8%. Almost none of the NT4-immunoreactive cells were reactive with anti-PGP 9.5 or the anti-NCAM antibody, but they could be stained with anti-gustducin, revealing that NT4-immunoreactive cells were contained only in the type-II--and possibly type-I--cell population. On the other hand, NT3-, and TrkB-immunoreactive cells included type-III cells, together with type-II, -I, and basal cells, because they were positive for PGP 9.5 and gustducin. We conclude that NT4 may exert t...Continue Reading

References

Mar 1, 1975·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·M Takeda, T Hoshino
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS P Squinto
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jan 1, 1985·The American Journal of Anatomy·A I FarbmanA Nelson
Nov 1, 1970·The Anatomical Record·S Fujimoto, R G Murray
Jun 1, 1969·Journal of Ultrastructure Research·R G MurrayS Fujimoto
Nov 1, 1965·The Journal of Cell Biology·L M Beidler, R L Smallman
Nov 14, 1983·Brain Research·R J ThompsonJ Rode
Jul 1, 1980·Cell and Tissue Kinetics·A I Farbman
Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Klein
May 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·R Götz, M Schartl
Jun 27, 1996·Nature·G T WongR F Margolskee
Oct 1, 1996·Cell and Tissue Research·M TakedaY Nagai
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B FritzschI Silos-Santiago
Feb 4, 1999·Annals of the New York Academy of Sciences·B Oakley
Apr 2, 1999·Journal of Electron Microscopy·M TakedaW Breipohl
Sep 10, 1999·Developmental Biology·D J LieblL F Parada
Sep 8, 2001·Cell and Tissue Research·G Dechant
Mar 12, 2003·The Journal of Comparative Neurology·Cindy L YeeThomas E Finger
Apr 22, 2003·Archives of Histology and Cytology·Nobuhiko UchidaMasako Takeda
Jan 1, 2004·Neuroscience Letters·A GermanaJ A Vega
Sep 25, 2004·The Journal of Comparative Neurology·Masako TakedaKentaro Kawakoshi

❮ Previous
Next ❯

Citations

Jul 25, 2009·Cell and Tissue Research·Akira Ito, Christopher A Nosrat
May 27, 2009·Archives of Oral Biology·A L MandelV Utermohlen
Oct 18, 2007·BMC Neuroscience·Robin F Krimm
Jun 11, 2017·Molecular and Cellular Neurosciences·Tao TangRobin Krimm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

The Journal of Comparative Neurology
Masako TakedaKentaro Kawakoshi
Journal of Electron Microscopy
M TakedaY Nagai
Archives of Histology and Cytology
Ryoko KohnoKuniaki Toyoshima
© 2021 Meta ULC. All rights reserved