Immunohistochemical detection of proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma

European Journal of Cancer. Part B, Oral Oncology
K FunaokaY Totsuka

Abstract

Ameloblastoma is the most frequent odontogenic tumour. It occurs mainly in the mandible and grows expansively. The treatment of ameloblastoma, which influences the prognosis, is decided in consideration of many factors, especially the age and size of the tumour. Conservative treatment sometimes leads to the recurrence of tumours and poor prognosis, but the relationships between the prognosis and the cytological features of tumour cells are still unclear. In the present study, we examined the immunohistochemical detection of proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma and evaluated the correlation between the positive index of PCNA and the clinical and histological character. Our results revealed the higher the age of the patient the greater was the incidence of a positive index of PCNA. It was also shown that the mean positive PCNA index in the follicular type (34.56 +/- 14.00 S.D.) was higher than that of the plexiform type (24.436 +/- 15.74 S.D., P < 0.10). The cystic type showed a low positive PCNA index (14.75 +/- 8.41 S.D.). In the follicular type, the localisation of PCNA-positive cells was different according to the histological patterns of tumours. Additionally, the positive indices of the sam...Continue Reading

References

Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K YasudaM Nagayama
Apr 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K YasudaY Hayashi
Jan 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S UenoR Shirasu
Oct 1, 1985·The British Journal of Oral & Maxillofacial Surgery·G StenmanS Sagne
Mar 1, 1981·Surgical Neurology·S TakeuchiM Fukushima
May 1, 1980·Plastic and Reconstructive Surgery·J O DaramolaJ O Oluwasanmi
Mar 1, 1995·European Journal of Cancer. Part B, Oral Oncology·K YamamotoT Osaki
Mar 1, 1995·European Journal of Cancer. Part B, Oral Oncology·P A ReichartS Sonner
Oct 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·G HoustonS Harris
Feb 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·E BadenV Petriella
Jun 1, 1993·The British Journal of Oral & Maxillofacial Surgery·I O ThompsonC W van Wyk
Jul 1, 1963·The British Journal of Oral Surgery·I R KRAMER

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Citations

Aug 8, 2002·Cancer Genetics and Cytogenetics·Karoliina JääskeläinenKristiina Heikinheimo
Feb 13, 2001·Oral Oncology·F SandraM Ohishi
Feb 13, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shabnum MeerHasiena Ali
Jun 30, 2011·Journal of Oral Science·Jahanshah SalehinejadParviz Marouzi
May 26, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ana Miryam Costa de MedeirosRoseana de Almeida Freitas
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Bk VarshaUma Swaminathan
Oct 9, 2001·The Bulletin of Tokyo Dental College·K HatadaG Yamane
Oct 16, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Aline Cristina Batista Rodrigues JohannRicardo Alves Mesquita
Aug 10, 2000·Histopathology·M AltiniE Maiorano
Aug 23, 2005·Brazilian Dental Journal·Carlos Augusto Galvão BarbozaLélia Batista de Souza
Jan 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R PayerasJ J D Barbachan
May 1, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M A do Carmo, E C Silva
May 18, 2020·Biointerphases·Hanieh Safizadeh ShiraziMelanie MacGregor
Jan 22, 2008·Oral Oncology·R Bologna-MolinaP Damián-Matsumura

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