Immunohistochemical detection of survivin in canine lymphoma

Journal of Comparative Pathology
J WimmershoffF Guscetti

Abstract

Survivin is a member of the family of proteins known as 'inhibitors of apoptosis proteins'. Survivin has a role in cellular decisions concerning division and survival and is frequently expressed in neoplastic cells. The aim of the present study was to investigate immunohistochemically the expression of survivin in normal canine tissues and in canine lymphoma. A representative range of fetal and adult normal tissues as well as biopsy samples from dogs with lymphoma were assembled in tissue arrays. The lymphomas were classified according to the revised Kiel and to the Revised European American Lymphoma-World Health Organization (REAL-WHO) schemes. Polyclonal and monoclonal antisera cross-reactive with canine survivin identified cytoplasmic expression of the molecule in a broad range of normal canine cells. The same reagents demonstrated cytoplasmic labelling of more than 5% of cells in all 83 lymphoma samples tested with polyclonal antiserum and in 67 of 82 (82%) of samples tested with monoclonal antiserum. Survivin was expressed by a wide range of canine lymphoma subtypes, but the expression of this molecule in normal canine tissues must be considered if novel therapies targeting survivin are applied to the management of canine ...Continue Reading

References

Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K KobayashiT Tokuhisa
Sep 1, 1999·The Journal of Investigative Dermatology·C ChiodinoC Pincelli
Dec 14, 1999·The Journal of Investigative Dermatology·D GrossmanD C Altieri
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·Guy S Salvesen, Colin S Duckett
Jul 10, 2002·Veterinary Pathology·C Fournel-FleuryJ P Magnol
Jan 27, 2004·The American Journal of Pathology·Antonio MartinezDolors Colomer
Feb 21, 2004·The Veterinary Journal·Frédérique PonceCorinne Fournel-Fleury
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen J SchletteGeorge Z Rassidakis
Oct 26, 2005·DNA Sequence : the Journal of DNA Sequencing and Mapping·Tsuyoshi UchideHiroshi Itoh
Feb 25, 2006·Journal of Veterinary Internal Medicine·Timothy J ScaseSue Murphy
May 30, 2006·Molecular Cancer Therapeutics·Seiji Fukuda, Louis M Pelus
Jul 10, 2007·Cancer Research·Roland H StauberShirley K Knauer
Oct 19, 2007·Leukemia & Lymphoma·Lin LiuPing Zou
Oct 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mads Hald AndersenPer Thor Straten
Nov 14, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Stefan M KellerFranco Guscetti
Dec 14, 2007·Nature Reviews. Cancer·Dario C Altieri
May 16, 2008·Journal of Comparative Pathology·M MurakamiT Masegi
Jul 24, 2008·Journal of Veterinary Internal Medicine·R B RebhunD H Thamm
Jan 31, 2009·Veterinary and Comparative Oncology·W Velando RankinJ A Green

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Citations

Aug 6, 2010·The Journal of Veterinary Medical Science·Miyuki MoriyamaHiroshi Kamata
Mar 10, 2016·The Veterinary Quarterly·M Zandvliet
Aug 31, 2013·The Veterinary Journal·Martina CrociFranco Guscetti
May 2, 2015·Polish Journal of Veterinary Sciences·J SokołowskaR Lechowski
Oct 28, 2019·Veterinary and Comparative Oncology·Katie A McNaughtMark McLaughlin

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