PMID: 9438903Jan 24, 1998Paper

Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin

Journal of Dermatological Science
R WatanabeT Ono

Abstract

Cutaneous fatty acid-binding protein (C-FABP) has been newly discovered from rat skin. The immunohistochemical study revealed that C-FABP is strongly expressed in rat epidermis. Recently, a highly homologous protein to rat C-FABP was found in psoriatic epidermis, which is termed psoriasis-associated fatty acid-binding protein (PA-FABP). In the present study, we investigated the expression of PA-FABP in normal and pathological human skin using immunohistochemical techniques. In normal skin, PA-FABP was expressed in basal and prickle cell layers, and more strongly in the granular cell layer. The expression pattern of PA-FABP was similar to that of C-FABP in rat skin. In psoriatic skin, PA-FABP was expressed in suprabasal layers and more strongly in more differentiated keratinocytes. In squamous cell carcinoma, PA-FABP showed very strong expression in squamous nests. These results indicate that PA-FABP is a human homologue of C-FABP. Moreover, it is suggested that C-FABP has important roles in the transport and metabolism of fatty acids in epidermis and that altered lipid metabolism may affect the proliferation and/or differentiation of keratinocyte.

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Citations

Apr 26, 2008·Annual Review of Nutrition·Judith Storch, Betina Corsico
Mar 17, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Teruo Ono, Shoji Odani
Jan 29, 2005·The Journal of Investigative Dermatology·Manon E J FranssenPiet E J van Erp
Dec 31, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lei-Ya FangYuh-Ling Chen
Jun 23, 2011·Dermato-endocrinology·Denis KhnykinFrode Jahnsen
Sep 1, 2005·Molecular and Cellular Biochemistry·Teruo Ono
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takahiro OhmachiMasaki Mori
Jul 3, 2021·Frontiers in Genetics·L E R BurrowsJ G H Hickford
Aug 8, 2021·Journal of Clinical Medicine·Masaru Honma, Hiroyoshi Nozaki
Oct 7, 2004·The American Journal of Pathology·Atsuko KamijoKenjiro Kimura

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