PMID: 2823456Jan 1, 1987Paper

Immunohistochemical distribution of human epidermal growth factor in salivary gland tumours

Virchows Archiv. A, Pathological Anatomy and Histopathology
M MoriK Kato

Abstract

Immunohistochemical identification of human epidermal growth factor (hEGF) was carried out in a total of 152 cases of salivary gland tumours, consisting 107 pleomorphic adenomas and their variants, 13 adenolymphomas and 32 adenoid cystic carcinomas. A high percentage of pleomorphic adenomas revealed markedly positive hEGF staining of the luminal surface cells of tubuloductal structures and of modified or neoplastic myoepithelial cells. Clear cells of the tumour showed various reactivities from very slight to strong. Eosinophilic epithelial cells of adenolymphoma gave a positive reaction for hEGF in all the cases, whereas most adenoid cystic adenoma lacked hEGF staining; however some cases showed positive staining of the tumour cells. The immunohistochemical detection of hEGF in most salivary gland tumours suggests this factor to be a possible new marker of salivary glands tumours, and to have a biological role in tumour proliferation.

References

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Citations

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·K YamadaM Mori
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·K ShirasunaT Matsuya
May 1, 1990·The Japanese Journal of Surgery·H MukaidaM Niimoto
Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ricardo S MacarencoMarie-Christine Aubry
Mar 11, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Eleni KatopodiStavros Papanicolaou
Feb 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cristiane FuruseVera Cavalcanti de Araújo
Dec 31, 2002·Pathologie-biologie·J C EgéaD Deville De Périère

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